Response 4: The introduction will be changed to contain: Sussmann et al. 2013 did a similar study on the inter-comparison of methane from MIR and NIR retrievals. They used a Tikhonov-L1 regularized profile retrieval scheme with the standard NDACC retrieval package SFIT2 for the MIR and the standard TCCON retrieval (GFIT) for the NIR spectra. They conclude that the obtainable information from th...

Transformation of macrophages to foam cells contributes to atherosclerosis. Here, we report that let-7g reduces macrophage transformation and alleviates foam cell apoptosis by suppressing both canonical and non-canonical NF-κB pathways. In the canonical pathway, let-7g inhibits phosphorylation of IKKβ and IκB, down-regulates SREBF2 and miR-33a, and up-regulates ABCA1. In the non-canonical pathw...

BACKGROUND This study sought to investigate crucial genes correlated with diabetic nephropathy (DN), and their potential functions, which might contribute to a better understanding of DN pathogenesis. METHODS The microarray dataset GSE1009 was downloaded from Gene Expression Omnibus, including 3 diabetic glomeruli samples and 3 healthy glomeruli samples. The differentially expressed genes (DE...

Aflatoxins are secondary metabolites produced by the fungi, Aspergillus avus and Aspergillus parasiticus and usually divided four major types, aflatoxin B1, B2, G1 and G2. Among these, AFB1 produced by Aspergillus avus is the most potent of these toxins, and has the highest hepatocarcinogenic potential (McLean et al., 1995; IARC, 2002). The binding of AFB1 to DNA is responsible for the inhibiti...