نتایج جستجو برای: mirna اینترونی مصنوعی

تعداد نتایج: 33577  

Journal: :Molecular pharmacology 2011
Rakesh C Kukreja Chang Yin Fadi N Salloum

MicroRNAs (miRNAs) have emerged as a novel class of endogenous, small, noncoding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs. Over 700 miRNAs have been identified and sequenced in humans, and the number of miRNA genes is estimated at more than 1000. Individual miRNA is functionally important as a transcription factor because it...

2016
Anne Haahr Mellergaard Eriksen Rikke Fredslund Andersen Boye Schnack Nielsen Flemming Brandt Sørensen Ane Lindegaard Appelt Anders Jakobsen Torben Frøstrup Hansen

INTRODUCTION An increasing number of studies have investigated microRNAs (miRNAs) as potential markers of diagnosis, treatment and prognosis. So far, agreement between studies has been minimal, which may in part be explained by intratumoral heterogeneity of miRNA expression. The aim of the present study was to assess the heterogeneity of a panel of selected miRNAs in rectal cancer, using two di...

Journal: :Genetics and molecular research : GMR 2013
Y Yang J Qiu Q Kan X-G Zhou X-Y Zhou

Over the past several years, several microRNA (miRNA) expression profiling studies have been carried out on bronchopulmonary dysplasia (BPD) in mammalian lung tissues. The most effective way to identify these important miRNAs is to systematically search for similar signatures identified in multiple independent studies. Accordingly, a meta-analysis was conducted to review published miRNA express...

2017
Ahmed Hussein Zedan Søren Garm Blavnsfeldt Torben Frøstrup Hansen Boye Schnack Nielsen Niels Marcussen Mindaugas Pleckaitis Palle Jörn Sloth Osther Flemming Brandt Sørensen

INTRODUCTION In the last decade microRNAs (miRNAs) have been widely investigated in prostate cancer (PCa) and have shown to be promising biomarkers in diagnostic, prognostic and predictive settings. However, tumor heterogeneity may influence miRNA expression. The aims of this study were to assess the impact of tumor heterogeneity, as demonstrated by a panel of selected miRNAs in PCa, and to cor...

2012
Karathanasis Nestoras Tsamardinos Ioannis P. Armen Angelos Poirazi Panayiota

We address the problem of predicting the miRNA:miRNA* duplex stemming from a microRNA (miRNA) hairpin precursor and we present a SVM-based methodology to address it. Predicting the miRNA:miRNA* duplex is a first step towards identifying the mature miRNA, suggesting possible miRNA targets and ultimately, reducing experimentation effort, time, and cost. We measure the error in terms of the absolu...

2015
Nicole Cloonan

Despite a library full of literature on miRNA biology, core issues relating to miRNA target detection, biological effect, and mode of action remain controversial. This essay proposes that the predominant mechanism of direct miRNA action is translational inhibition, whereas the bulk of miRNA effects are mRNA based. It explores several issues confounding miRNA target detection, and discusses thei...

Journal: : 2023

Alzheimer's disease (AD) is a multifactorial resulting from both genetic and environmental factors, which are pathologically defined by the accumulation of intracellular hyperphosphorylated tau protein, neurofibrils tangles, extracellular amyloid β protein in brain. The purpose this study to estimate potentially damaging effects missense single nucleotide polymorphisms (SNPs) BID, MAPK10 AGER g...

2015
Daekyoung Jung Bohyoung Kim Robert J Freishtat Mamta Giri Eric Hoffman Jinwook Seo

BACKGROUND MicroRNAs (miRNA) are short nucleotides that down-regulate its target genes. Various miRNA target prediction algorithms have used sequence complementarity between miRNA and its targets. Recently, other algorithms tried to improve sequence-based miRNA target prediction by exploiting miRNA-mRNA expression profile data. Some web-based tools are also introduced to help researchers predic...

Journal: :Sensors & diagnostics 2022

miRNA analysis simplified using multi-ChemiRNA Tech.

Journal: :iranian journal of allergy, asthma and immunology 0
zahra alizadeh immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran esmaeil mortaz department of immunology, nritld, shahid beheshti university of medical sciences, tehran, iran and division of pharmacology and pathophysiology, utrecht institute for pharmaceutical sciences, faculty of sciences, utrecht university, utrecht, the netherlands ian adcock airway disease section, national heart and lung institute, imperial college london, london, uk moatafa moin immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran

asthma is a complex, heterogeneous and chronic airway inflammatory disease with different clinical phenotypes caused by diverse triggers and pathophysiological mechanisms. asthma heritability has been established in many genetic studies but it is evident that only genetic elements are not responsible for the development of asthma. increasing rate of asthma incidence during past decades has impl...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید