Inherited paternal HLA antigens from the semi-allogeneic fetus may trigger maternal immune responses during pregnancy, leading to the production of child-specific HLA antibodies. The prevalence of these HLA antibodies increases with the number of successful pregnancies. In the present study, we investigated the effect of a single prior miscarriage on HLA antibody formation during a subsequent s...

BACKGROUND SYCP3 mutations have been shown to generate an aberrant synaptonemal complex in a dominant-negative manner and to contribute to abnormal chromosomal behavior that might lead to recurrent miscarriage. We examined whether SYCP3 mutation is associated with recurrent miscarriage caused by embryonic aneuploidy. METHODS The SYCP3 657T>C mutation was examined using PCR and sequencing in 1...

OBJECTIVE To report the prospective outcomes of medical management of missed miscarriage before 13 weeks' gestation from an Australian cohort. DESIGN Descriptive study of a cohort selected out of a randomised controlled trial. SETTING Outpatient management at a maternity hospital between 1 May 2007 and 28 July 2010. PARTICIPANTS 264 women requesting medical management of missed miscarriag...

There is an error in the last sentence of the Data synthesis section of the Abstract. The correct sentence is: No study reported adjusted estimates in the miscarriage review, therefore results are presented individually. There is an error in the 13th sentence of the Characteristics of Studies Included in the Miscarriage Review section of the Results. The correct sentence is: No study in the mis...

OBJECTIVE To evaluate whether prenatal use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with increased risk of miscarriage. DESIGN Population based cohort study. Prenatal use of NSAIDs, aspirin, and paracetamol (acetaminophen) ascertained by in-person interview. SETTING Kaiser Permanente Medical Care Program, a healthcare delivery system, in the San Francisco area of the ...

A miscarriage can be very traumatic for a couple and their immediate family. The aim of this study was to assess, using the Perinatal Grief Scale (PGS), whether the type of early pregnancy loss influences the severity of grief and whether the presence of living children influences the severity of grief. Over a period of 6 months in 2008, seventy five patients were recruited for the study, of wh...

BACKGROUND The increase in miscarriage rate with female age is attributed to a decline in oocyte quality. This age-related decrease of oocyte quality is accompanied by a decrease in oocyte quantity. Assessment of the number of oocytes by ovarian reserve tests (ORTs) may therefore also represent their quality. The objective of our study was to assess the predictive value of ORTs for miscarriage ...

OBJECTIVES To identify and prioritise important research questions for miscarriage. DESIGN A priority setting partnership using prospective surveys and consensus meetings following methods advocated by the James Lind Alliance. SETTING UK. PARTICIPANTS Women and those affected by miscarriage working alongside healthcare professionals. RESULTS In the initial survey, 1093 participants (932...

Miscarriage is the most common complication of human pregnancy. Although the causes of recurrent miscarriage (RM) are various, immunologic aberrations between mother and fetus might be one of the causes of miscarriage. Immune responses fall into two categories: autoimmune and alloimmune. Currently, no appropriate diagnostic method has been established to identify alloimmune causes. We observed ...

OBJECTIVES To assess whether bacterial vaginosis or chlamydial infection before 10 weeks' gestation is associated with miscarriage before 16 weeks. DESIGN Prospective cohort study. SETTING 32 general practices and five family planning clinics in south London. PARTICIPANTS 1216 pregnant women, mean age 31, presenting before 10 weeks' gestation. MAIN OUTCOME MEASURE Prevalence of miscarri...