OBJECTIVE To compare the efficacy of external dacryocystorhinostomy (DCR) with and without intraoperative application of mitomycin-C in patients with chronic dacryocystitis. STUDY DESIGN An experimental study. PLACE AND DURATION OF STUDY Department of Ophthalmology, Bahawal Victoria Hospital (BVH), Bahawalpur, from September 2009 to December 2010. METHODOLOGY One hundred and sixty patient...

AIMS To evaluate the effect of T cell co-culture on mitomycin C treated and untreated Tenon's capsule fibroblasts. METHODS IL-2 dependent allogeneic T cells were incubated over a monolayer of mitomycin C treated or control fibroblasts. Fibroblast numbers were evaluated by direct counts using phase contrast microscopy. To determine whether T cell mediated lysis was a consequence of MHC mismatc...

Hypoxie cells of solid tumors are relatively resistant to therapeutic assault. Studies have demonstrated that oxygen-deficient tumor cells exist in an environment conducive to reductive reactions making hypoxic cells particularly sensitive to bioreductive alkylating agents. Mitomycin C, the prototype bioreductive alkylating agent available for clinical use, is capable of preferentially killing ...

Despite various developments in many fields of ophthalmology, the surgical therapy of open-angle glaucoma has remained mostly unchanged over the last 30 years. Ever since the introduction of intraoperative mitomycin and postoperative subconjunctival injections of 5-fluorouracil (5-FU), trabeculectomy has not markedly been altered. These facts stand in contrast to the need for a more efficient s...

Physico-chemical properties, molecular interactions and thermodynamic stability of human and bovine serum albumins in complexes with mitomycin C were investigated. The pH and temperature influence on serum albumins properties and the binding mechanism of mitomycin C to these proteins have been monitored by spectrometry and spectrofluorimetry methods.

Sir: Mitomycin C is a clinically useful antineoplastic antibiotic compound1)2),but its use is limited by side effects, such as severe bone marrowsuppression or gastrointestinal damage. In the hope of obtaining compounds with improved therapeutic properties, a number of derivatives have been prepared. Preparation of new mitomycin analogues have involved substituents on the aziridine ring3'40, an...

background: l1 retrotransposons are the most active mobile dna elements in human genome. unregulated l1 retrotransposition may have deleterious effect by disrupting vital genes and inducing genomic instabilities. therefore, human cells control l1 elements by silencing their activities through epigenetic mechanisms. it has been shown that cell division and heavy metals stimulate the frequency of...

A case of oral submucous fibrosis in a 45-year-old woman discusses its etiopathogenesis, clinical features the condition and highlights strong association areca nut chewing as potential factor etiology this condition. Cessation habit submucosal administration mitomycin triamcinolone acetonide along with active physiotherapy exercises showed marked improvement

purpose:  to determine the safety and efficacy of mitomycin-c injection into the lacrimal duct for treatment of partial nasolacrimal duct obstruction in adults. method: this is a before-after clinical trial performed on 20 patients with partial primary acquired nasolacrimal duct obstruction. we injected 1.5 ml of mitomycin-c 0.2 mg/ml into the lacrimal duct and repeated it with concentration of...