The supernova yields of r-process elements are obtained as a function of the mass of their progenitor stars from the abundance patterns of extremely metalpoor stars on the left-side [Ba/Mg]-[Mg/H] boundary with a procedure proposed by Tsujimoto and Shigeyama. The ejected masses of r-process elements associated with stars of progenitor massMms ≤ 18M⊙ are infertile sources and the SNe II with 20M...

The nature of DNA sequence changes induced by methyl methanesulfonate (MMS) at the vermilion locus of Drosophila melanogaster was determined after exposure of postmeiotic male germ cell stages. MMS is a carcinogen with strong preference for base nitrogen alkylation (s = 0.86). The spectrum of 40 intralocus mutations was dominated by AT----GC transitions (23%), AT----TA transversions (54%) and d...

BACKGROUND Mohs micrographic surgery (MMS) has a low rate of surgical site infection (SSI) without the use of prophylactic antibiotics. In the studies to date, there has been variation in the steps taken by each surgeon to prevent SSIs but in all cases sterile technique was used during wound reconstruction. OBJECTIVE We sought to evaluate the rate of SSIs among patients undergoing MMS with th...

BACKGROUND Mohs micrographic surgery (MMS) is used to treat certain high-risk non-melanoma skin cancers (NMSC) due to its high cure rate. However, clinical recurrences do occur in a small number of cases. OBJECTIVE We examined specific clinical characteristics associated with NMSC recurrences following MMS. METHODS We employed a retrospective chart review of the 1467 cases of NMSC that unde...

Objectives. To study the utility of the Mini-Cog test for detection of patients with cognitive impairment (CI) in primary care (PC). Methods. We pooled data from two phase III studies conducted in Spain. Patients with complaints or suspicion of CI were consecutively recruited by PC physicians. The cognitive diagnosis was performed by an expert neurologist, after formal neuropsychological evalua...

We hereby present different DNA nanocarriers consisting of new multimodular systems (MMS), containing the cationic lipid dioleylaminesuccinylparomomycin (DNA MMS DOSP), or bis (guanidinium)-tren-cholesterol (DNA MMS BGTC), and DNA lipid nanocapsules (DNA LNCs). Active targeting of the asialoglycoprotein receptor (ASGP-R) using galactose as a ligand for DNA MMS (GAL DNA MMS) and passive targetin...

Buildings are responsible for roughly one third of greenhouse gas (GHG) emissions within developed countries, yet space utilization efficiency is still a widely unidentified topic. With the sector only starting to become aware of it as a means to reduce GHG emissions and save (financial) resources there are hardly any strategies to improve space utilization efficiency. Mathematical modeling and...

BACKGROUND The clinical application of nimodipine (NIM) is limited by several unfavorable properties, which are induced by its low aqueous solubility. In the present study, nimodipine-loaded egg phosphatidylcholine-sodium glycocholate mixed micelles (NIM-EPC-SGC-MMs) were prepared to improve the water solubility of NIM, thus allowing it to be more applicable for clinical use. METHODS NIM-EPC-...

To better understand alkylating agent-induced cytotoxicity and the base lesion DNA repair process in Saccharomyces cerevisiae, we replaced the RAD27(FEN1) open reading frame (ORF) with the ORF of the bifunctional human repair enzyme DNA polymerase (Pol) β. The aim was to probe the effect of removal of the incised abasic site 5'-sugar phosphate group (i.e., 5'-deoxyribose phosphate or 5'-dRP) in...

Model management is a research area in decision support systems (DSS). Current research trends emphasize the specification of decision models at the conceptual level rather than their detailed implementation. Several approaches have been proposed for the conceptual specification of model management systems (MMS). However, these methods lack the design theory for the discovery of the inheritance...