In the present work, an amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral stationary phase (CSP) was prepared by coating ADMPC on small-particle silica gel. This ADMPC-CSP was for the first time successfully applied to separate a series of novel chiral metal tetrahedrane-type clusters. Furthermore, the influence of a mobile-phase modifier (various alcohols added in the mobile phase), inc...

This paper describes a reversed-phase liquid chromatographic method for the determination of vanillin, associated natural aromatic compounds and/or synthetic precursors, ethyl vanillin, and coumarin, a commonly encountered adulterant in nonbeverage and beverage alcohol products using a ternary gradient mobile phase. The compounds were separated on a Nova-Pak C18 column by using water, methanol,...

A simple, fast, and sensitive reversed-phase HPLC method with UV detection was developed for the quantitation of omeprazole and its eleven related compounds (impurities) in pharmaceutical formulation using the Thermo Accucore C-18 (50 mm × 4.6 mm, 2.6 μm) column. The separation among all the compounds was achieved with a flow rate of 0.8 mL min(-1) employing a gradient program of mobile phase A...

The present study is carried out for the analytical development and formulation of ramipril and hydrochlorothiazide in combination with selective excipients. The objective of drug and excipient compatibility considerations and practical studies is to delineate, as quickly as possible, real and possible interactions between potential formulation excipients and the Active Pharmaceutical Ingredien...

zataria multiflora boiss is used in traditional folk remedies as antiseptic, analgesic, carminative, anthelmintic medication. the main components of zataria multiflora are phenolic compounds such as thymol and carvacrol. the aim of this study was developed a simple and rapid method for determination of the thymol in different extracts of zataria multiflora by hplc method. the dried aerial parts...

and Yan (5) reported that they successfully separated high polarity explosives using CEC with nonporous C18-coated material and a mobile phase with a low concentration of organic modifier and SDS added to the mobile phase to increase the wettability of the particle surface. Zhang and colleagues (9) also reported that very polar compounds could be separated by mixed-packing CEC with a stationary...

mobile carrier properties of two schiff base ligands, named bis(2-hydroxypropiophenone)-1,2-propanediimine (n2o2) and bis(1'-hydroxy-2'-acetonaphthone)-2,2'-diiminodiethylamine (n3o2), dissolved in dichloromethane for the extraction of copper(ii) ions from an ammonium buffer feed phase into a nitric acid solution (receiving phase) were investigated and compared. the parameters influencing the t...

Normal phase, isocratic high-performance liquid chromatography methods are described for the separation of neutral lipid and fatty acid classes using low wavelength detection. Prior to high-performance liquid chromatography, methods were developed and are described for the separation of phospholipids from neutral lipids and fatty acids using small (600 mg) silica Sep-PaksTM. Recoveries of chole...

The separation of chiral transformation products greatly complements the understanding of the stereochemistry of chiral pollutants. In this study, direct enantiomeric resolution of metalaxyl and its main degradation product metalaxyl acid, often co-occurring in the environment, was carried out in normal-phase high-performance liquid chromatography with a Chiralcel OJ-H column. (R)-Metalaxyl aci...