A two-way linear mixed model with three variance components as 1, 2 2 and 2 e is applied to evaluate the performance of modi…ed Henderson’s method 3 developed by Al-Sarraj and Rosen (2007). The focus of modi…ed procedure is on the estimation of 1 which variance components is mainly concerned. The modi…ed estimator is expected to perform better than unmodi…ed Henderson’s method 3 in terms of MSE...

ARC AND PATH CONSISTENCY REVISITED' Roger Mohr and Thomas C. Henderson 2 CRIN BP 239 54506 Vandoeuvre (France)

Contributing Authors: K. AchutaRao (USA), R. Allan (UK), A. Berger (Belgium), H. Blatter (Switzerland), C. Bonfi ls (USA, France), A. Boone (France, USA), C. Bretherton (USA), A. Broccoli (USA), V. Brovkin (Germany, Russian Federation), W. Cai (Australia), M. Claussen (Germany), P. Dirmeyer (USA), C. Doutriaux (USA, France), H. Drange (Norway), J.-L. Dufresne (France), S. Emori (Japan), P. Fors...

While individual agent-oriented methodologies are useful for restricted situations, for wider industry adoption it is useful to create a methodological framework that provides method fragments from which situationally specific methodologies can be constructed. Such a flexible approach can be found in the use of situational method engineering (SME). In this context, this article describes the de...

Alex Avdeef [1] and Samuel Yalkowsky [2] have independently studied the solubility and ionization properties of an investigational drug (NSC-639829). In the study conducted by Avdeef and coworkers, the pKa value derived from Henderson-Hasselbalch (HH) equation was 4.70, which was different from the value of 3.76 as determined experimentally by the Yasuda-Shedlovsky plot using the pKa values obt...