It is now increasingly apparent that modifier genes have a considerable role to play in phenotypic variations of single-gene disorders. Intrafamilial variations, altered penetrance, and altered severity are now common features of single gene disorders because of the involvement of several genes in the expression of the disease phenotype. Oligogenic disorders occur because of a second gene modif...

X-ray diffraction experiments of molten oxide glasses, which give new insights into the structure of melts, were carried out. Using modern means (synchrotron radiation, image plates, container-less hightemperature technique) it could be shown that the short range order of melt and solid glass is often qualitatively different. If vitreous B203 or binary borate glasses with low content of network...

Structural priming occurs when interlocutors copy the syntactic structure of their partners’ utterances, and is diagnostic of their underlying representations. We trained adult participants on an artificial ‘alien’ language in which nouns appeared with adjectives or numerals in two-word phrases; participants then used that language to communicate with an alien interlocutor. Input languages had ...

Subjects read and recalled a series of five short stories in one of four plot and style combinations. The stories were written in one of two styles that consisted of opposing clause orders (i.e., independent-dependent vs. dependent-independent), tense forms (i.e., past vs. present), and descriptor forms (modifier modifier vs. modifier as a noun). The subjects incorporated both plot and style ch...

The essential oil of Marchantia convoluta was obtained by supercritical (carbon dioxide) extraction using methanol as a modifier. Global yields were determined according to the orthogonal design. The effects of different parameters, such as pressure, temperature, modifier volume and extraction time, on the supercritical fluid extraction (SFE) of essential oil from M. convoluta were investigated...

The modifier effect is the reduction in judged likelihood of a generic statement (Apples are sweet) when the subject is modified (Chinese apples are sweet). Connolly, Fodor, Gleitman and Gleitman, (2007) argued that this effect undermines the principle of default property inheritance in conceptual combination. In a series of studies, we replicated the effect and its interaction with modifier ty...

Mutations in voltage-gated ion channels are responsible for several types of epilepsy. Genetic epilepsies often exhibit variable severity in individuals with the same mutation, which may be due to variation in genetic modifiers. The Scn2a(Q54) transgenic mouse model has a sodium channel mutation and exhibits epilepsy with strain-dependent severity. We previously mapped modifier loci that influe...