During lens development in vertebrates, the orchestration of multiple transcriptional regulators is essential for fate determination and terminal differentiation. In early development, Pax6, Sox2 and Six3 are expressed in the head ectoderm, while L-maf, Prox1 and crystallin genes are expressed at a later stage in the lens placode in a more restricted fashion. To uncover the genetic interactions...

The soil surface layer is a critical boundary between land and atmosphere, and soil moisture is a critical condition affecting interaction of land surface and atmosphere. The root zone can be defined as the top 100 cm of the soil layer. Remotely sensed data can indirectly measure soil moisture, but the signal only penetrates the top few centimeters, so soil moisture at deeper layers must be est...

OBJECTIVES To evaluate and compare the efficiency of humidification in available heat and moisture exchanger models under conditions of varying tidal volume, respiratory rate, and flow rate. INTRODUCTION Inspired gases are routinely preconditioned by heat and moisture exchangers to provide a heat and water content similar to that provided normally by the nose and upper airways. The absolute h...

Abstract Current approaches for the prospective regulatory assessment of chemicals do not account sufficiently elevated mixture risks. The Mixture Assessment Factor (MAF, better labeled a Allocation Factor) has been suggested mixtures industrial in EU’s Chemicals Strategy Sustainability, as pragmatic tool to potential risks already during risk and safety individual chemicals. MAF is be applied ...

This study establishes the recombinant expression system of MAF-1 (Musca domestica antifungal peptide-1) and demonstrates the antifungal activity of the expression product and shows the relationship between biological activity and structure. The gene segments on mature peptide part of MAF-1 were cloned, based on the primers designed according to the cDNA sequence of MAF-1. We constructed the re...

The combined effect of soil moisture in unsaturated soil layers and pore-water pressure in saturated soil layers is critical to predict landslides. An improved infinite slope stability model, that directly includes unsaturated zone soil moisture and groundwater, is derived and used to analyze the factor of safety’s sensitivity to unsaturated zone soil moisture. This sensitivity, the change in t...

Despite the importance of the coupling between vegetation dynamics and root-zone soil moisture in land-atmosphere interactions, there is no land data assimilation system (LDAS) that currently addresses this issue, limiting the capacity to positively impact weather and seasonal forecasting. We develop a new LDAS that can improve the skill of an ecohydrological model to simulate simultaneously su...

BACKGROUND Multiple myeloma (MM) is a type of hematological malignancy with significant heterogeneity in clinical features and prognosis. Cytogenetic abnormalities are the major factors affecting patient outcomes. Studies have shown that immunohistochemistry (IHC)-based detection of cancer-related genes expression could be alternative indicators for the prognosis of MM. METHODS Nuclear expres...

Epidemiological differences exist between Mycobacterium africanum (Maf)- and Mycobacterium tuberculosis (Mtb)-infected patients, but to date, contributing host factors have not been characterised. We analysed clinical outcomes, as well as soluble markers and gene expression profiles in unstimulated, and ESAT6/CFP-10-, whole-Maf- and Mtb-stimulated blood samples of 26 Maf- and 49 Mtb-HIV-negativ...