نتایج جستجو برای: molecular differentiation
تعداد نتایج: 836041 فیلتر نتایج به سال:
The molecular events that modulate chromatin structure during skeletal muscle differentiation are still poorly understood. We report in this paper that expression of the H3-K4 histone methyltransferase Set7 is increased when myoblasts differentiate into myotubes and is required for skeletal muscle development, expression of muscle contractile proteins, and myofibril assembly. Knockdown of Set7 ...
Directed differentiation is the process which selectively induce differentiation of stem cells toward definitive cells, but how directed differentiation occurs when stem cells confront the external cues has not been established theoretically. We demonstrate here directed differentiation of a simplified two-component network by using systematic parameter perturbations. These methods and results ...
Abstract IgA nephropathy (IgAN) is the most common type of autoimmune glomerulonephritis that frequently progresses to end-stage renal disease. However, molecular pathogenesis underlying IgAN remains largely unknown. This study investigated role galectin-3 (Gal-3), a galactoside-binding protein in pathogenesis. Two complementary mouse models, model induced with TEPC-15 hybridoma using Gal-3 kno...
Differentiation is a key feature in pathologic classification and prognosis of neuroblastic tumors, although the underlying molecular mechanisms are not well defined. To identify key differentiation-related molecules and pathways, we evaluated gene expression during retinoic acid (RA)-induced differentiation of seven neuroblastic tumor cell lines. Transcriptional response to RA was highly varia...
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