Clusters composed of a 32 silver atom core, protected with thiolates of glutathione (GSH) and N-(2-mercaptopropionyl)glycine (MPGH), were synthesized by a solid-state route in milligram scale. They do not exhibit surface plasmon resonance unlike their larger sized nanoparticle analogues but show molecule-like features in absorption and luminescence spectra, falling in the visible window. The co...

A report of the meeting “Challenges in experimental data integration within genomescale metabolic models”, Institut Henri Poincaré, Paris, October 10-11 2009, organized by the CNRS-MPG joint program in Systems Biology.

The DNA damage response (DDR) is activated by various genotoxic stresses. Base lesions, which are structurally simple and predominantly fixed by base excision repair (BER), can trigger the ataxia telangiectasia mutated (ATM)-checkpoint kinase 2 (Chk2) pathway, a DDR component. How these lesions trigger DDR remains unclear. Here we show that, for alkylation damage, methylpurine-DNA glycosylase (...

PURPOSE To improve the treatment of women with ovarian cancer, we are investigating the modulation of a prominent DNA-damaging agent, temozolomide, by manipulating the DNA base excision repair (BER) pathway via BER inhibitor, methoxyamine, and overexpression of N-methylpurine DNA glycosylase (MPG). EXPERIMENTAL DESIGN Enhancement of temozolomide via methoxyamine and MPG overexpression was ana...

This paper presents the application of neuro-fuzzy method for prediction of vehicle fuel consumption prediction. Prediction motor vehicle fuel consumption has become a strategic issue, because it is not only related to the issue of availability of fuel but also the problem of the environmental impact caused. This study used automobile data, i.e. number of cylinders, displacement, horsepower, we...

Human fibrosarcoma cells, HT-1080, feature extensive adherens junctions, lack mature desmosomes, and express a single known desmosomal protein, Desmoglein 2 (Dsg2). Transfection of these cells with bovine Desmocollin 1a (Dsc1a) caused dramatic changes in the subcellular distribution of endogenous Dsg2. Both cadherins clustered in the areas of the adherens junctions, whereas only a minor portion...

Graphitic carbon nitride materials have attracted significant interest in recent years and found applications diverse light-to-energy conversions such as artificial photosynthesis, CO2 reduction, or degradation of organic pollutants. However, their utilization synthetic photocatalysis, especially the direct functionalization C(sp3)–H bonds, remains underexplored. Herein, we report mesoporous gr...

The physical and mechanical properties of foamed geopolymers were determined. made with two different metakaolins (from Metacaulim do Brasil - MB, Pantano Grande/RS MPG) as precursors, NaOH Na2SiO3 activators, the addition foam, which was produced foaming agent diethanolamide coconut fatty acid a minimum 80% concentration. Also, times (2.5 4 h) used for calcination MPG at 750 °C. results showed...

a method for the controllable synthesis of silver nanoparticles based on a complexing agent method was developed. citric acid was used as a complexing agent. the effect of ph (1.6 to 5.17) on the size and net height (as obtained from xrd analyses) of silver nanoparticles was investigated. the nanoparticles (10 to 40 nm) were characterized using xrd, tem, sem, edx, uv-vis spectroscopy and tg/dtg...

Although habitat restoration can play a key role in the conservation of imperiled species, for animals that demonstrate long migrations and complex life histories, reliance on physical restoration of isolated habitat patches comes with considerable uncertainty. Nevertheless, within freshwater ecosystems, stream restoration has become a major conservation focus, with millions of dollars spent an...