The delivery systems of two long-acting formulations of methylphenidate (MPH) were designed for different durations. Diffucaps bead-delivery system (DBDS)-MPH was designed to last 8 h and osmotically controlled-release oral delivery system (OROS)-MPH was designed to last 12 h. While the plasma pharmacokinetics and timing of efficacy have been studied, the corresponding central nervous system do...

BACKGROUND Methylphenidate (MPH), a psychostimulant drug used to treat attention-deficit/hyperactivity disorder, produces the effects of increasing alertness and improving attention. However, misuse of MPH has been associated with an increased risk of aggression and psychosis. We sought to determine the molecular mechanism underlying the complex actions of MPH. METHODS Adolescent (4-week-old)...

Nicola P. Klein, MD, PhD; Ned Lewis, MPH; Kristin Goddard, Bruce Fireman, MA; Ousseny Zerbo, Kayla E. Hanson, James G. Donahue, DVM, Elyse O. Kharbanda, Allison Naleway, Jennifer Clark Nelson, Stan Xu, W. Katherine Yih, PhD, Jason M. Glanz, Joshua T. B. Williams, MD; Simon J. Hambidge, Bruno Lewin, Tom Shimabukuro, MPH, MBA; Frank DeStefano, Eric S. Weintraub, MPH

598. Hepatitis B Reactivation and Hemodialysis-Related Transmission Sarah Rhea, DVM, MPH, PhD; Robert Pace, RN; Victoria Mobley, MD, MPH; JenniferMacfarquhar, RN, MPH, CIC; Edward RobinsonJr., MD,MPH; Tonya Hayden, PhD; Hong Thai, PhD; John T. Brooks, MD; Anne Moorman, BSN, MPH; Priti Patel, MD, MPH; ZackMoore, MD,MPH; Epidemic Intelligence Service, Centers for Disease Control and Prevention; N...

The present study examined the effect of methylphenidate (MPH), a psychostimulant, on nor-adrenergic transmission in the locus coeruleus (LC) of juvenile rats. Intracellular recordings showed that MPH (>3 µM) produced a hyperpolarizing response associated with a decrease in the rate of spontaneously firing action potentials. MPH (1 µM) enhanced the amplitude of the inhibitory postsynaptic poten...

1 From the Department of Radiology, Riley Hospital for Children, Indianapolis, Ind (K.E.A.); Department of Radiology, Boston University, 88 E Newton St, Atrium 2, Boston, MA 02118 (R.T.); and Departments of Radiology and Biostatistics, Indiana University School of Medicine, Indianapolis (J.Y.). Received October 16, 2002; revision requested February 18, 2003; final revision received March 13; ac...