Objective(s):Previous studies demonstrate that changes in pre-mRNA splicing play a significant role in human disease development. Furthermore, many cancer-associated genes are regulated by alternative splicing. There are mounting evidences that splice variants which express predominantly in tumors, have clear diagnostic value and may provide potential drug targets. Located on the X chromosome, ...

objective(s):breast cancer is an important leading cause of death from cancer. stathmin and tau proteins are regulators of cell motility, and their overexpression is associated with the progression and bad prognosis of breast cancer. memantine, an n-methyl-d-aspartate (nmda) receptor antagonist, is the potential inhibitor of tau protein in neurons. this study determines the effect of memantine ...

osteosarcoma is a relatively uncommon malignancy however, it is the most common form of primary malignant bone tumors in human. diagnosis and prognosis of patients with osteosarcoma is limited to clinico-radiopathological parameters, whereas molecular markers of tumor aggression have been poorly identified. survivin, an inhibitor of apoptosis (iap), is unique for its expression in human tumors ...

nitrate is one of the major sources of nitrogen for the growth of plants. it is taken up by plant roots and transported to the leaves where it is reduced to nitrite in the. the main objective of this research was to investigate stimulatory effects of sodium nitrate, potassium nitrate, ammonia and urea on the production/generation of the nitrate reductase mrna in triticum aestivum plants. the pl...

introduction: nicotinamide adenine dinucleotide phosphate (nadph) oxidase-2 (nox2) is one of the predominant sources of ros production during myocardial ischemia-reperfusion and can be induced by angiotensin ii. the evidence suggests that pharmacological blockers of renin-angiotensin system can exert direct tissue effects independent of their ability to regulate blood pressure. the mechanism(s)...

Background: In fertile women, glycodelin and glutathione peroxidase 3 (GPx3) genes expression rises during the luteal phase, with a peak occurring during the implantation window. The expression of these genes decreases in women with myomas. To determine whether myomectomy would reverse glycodelin and GPx3 expression, we evaluated the transcript levels of these genes in the endometrium of patien...

Background: Efficient screening for detection of colorectal cancer (CRC) at earlier stages reduces its mortality. The purpose of this study was to investigate expression of carcinoembryonic antigen (CEA) and human telomerase reverse transcriptase (hTERT) mRNA in peripheral blood of CRC patients and to present strategies for early detection screen test. Methods: Twenty seven patients in non-meta...

objective: osteopontin (opn) has been proposed to play a role in bone resorption. with regard to bone and cementum/dentin structural and histological similarities, it was hy-pothesized that expression of this gene might be increased in resorptive lacunae during orthodontic tooth movement. materials and methods: fixed nickel-titanium closed coil springs (dentaurum ® ) capa-ble of delivering appr...

objective: diabetic neuropathy leads to axonal transport abnormalities. however its mechanism and the beneficial effects of exercise on these abnormalities are not well documented. the present study aims to investigate kif1b mrna in spinal cord sensory neuron tissue of wistar male rats with diabetic neuropathy following endurance training. methods: we randomly assigned 12 male wistar rats into ...

Abstract The mRNA epitranscriptome imparts diversity to gene expression by installing chemical modifications. Advances in detection methods have identified modifications eukaryotic, bacterial, and viral messenger RNAs (mRNAs). biological functions of mRNAs still remain be understood. Chemical are introduced synthetic meant for therapeutic applications maximize from the evade host immune respons...