INTRODUCTION The murine air pouch is a bursa-like space that resembles the human synovial membrane. Injection of monosodium urate (MSU) crystals into the pouch elicits an acute inflammatory response similar to human gout. We conducted the present study to identify mRNAs that were highly regulated by MSU crystals in the pouch membrane. METHODS Air pouch membranes were meticulously dissected aw...

The cAMP-response element-binding protein (CREB)-binding protein and p300 are two highly conserved transcriptional coactivators and histone acetyltransferases that integrate signals from diverse signal transduction pathways in the nucleus and also link chromatin remodeling with transcription. In this report, we have examined the role of p300 in the control of the G(1) phase of the cell cycle in...

Collecting midstream specimens of urine (MSU) is a common nursing activity. It is indicated for adults and children who are continent and can empty their bladder on request. The general principle is to collect the midstream or middle part of a void if a urinary tract infection (UTI) is suspected. Since this is one of the most frequently occurring infections, an MSU may be required in many areas...

An off-the-shelf Raman Spectrometer (RS) was used to noninvasively determine the presence of monosodium urate (MSU) crystals on the metatarsophalangeal joint (MTPJ) of a single gout sufferer. The spectrum sourced from the clinically diagnosed gout sufferer was compared to that sourced from an age-matched healthy subject scanned using the same protocol. Minimal signal processing was conducted on...

Welcome to Michigan State University. It is our hope that your life at MSU will be fulfilling and successful, now and in the future. To enable you to begin the process of learning the lay of the land at MSU, we have created this orientation website designed specifically for New Administrators, including new Executive Managers, Deans, Associate and Assistant Deans, Department Chairs, and School ...

Children in the back seat on a long trip are not the only ones asking the question “Are we there yet?” At Murray State University (MSU) and other universities starting new programs, the question becomes one of validation of the program. In the late 90s, MSU, a midsize university, was entrusted with the responsibility of developing a program of distinction with financial support from special sta...

BACKGROUND Dual-energy computed tomography (DECT) is a new diagnostic tool for gout, but its sensitivity has not been established. Our goal was to assess the sensitivity of DECT for the detection of monosodium urate (MSU) deposits in non-tophaceous and tophaceous gout, both at the level of the patient and that of the individual joint or lesion. METHODS DECT was performed on 11 patients with c...

INTRODUCTION The melanocortin peptides have marked anti-inflammatory potential, primarily through inhibition of proinflammatory cytokine production and action on phagocytic cell functions. Gout is an acute form of arthritis caused by the deposition of urate crystals, in which phagocytic cells and cytokines play a major pathogenic role. We examined whether alpha-melanocyte-stimulating hormone (a...

Results are presented from the exposure of a CMS performance prototype MSGC to a fast neutron beam having an average energy of 20 MeV and an intensity of 7 106 neutrons/mm2/s. A fluence equivalent to 3 years of LHC operation has been accumulated without damages to the detector. The stability of the MSGC operation in a heavily ionising particle flux is reported and the estimation of their produc...

Welcome to Michigan State University. It is our hope that your life at MSU will be fulfilling and successful, now and in the future. To enable you to begin the process of learning the lay of the land at MSU, we have created this orientation website designed specifically for New Administrators, including new Executive Managers, Deans, Associate and Assistant Deans, Department Chairs, and School ...