The purpose of the research was to formulate microspheres of acyclovir (ACV) using mucoadhesive polymers, sodium alginate and chitosan. Calcium chloride was used as the ionotropic gelling agent. Sodium alginate was crosslinked by calcium chloride leading to a slower release of the drug. Chitosan which is a cationic polymer interacted with sodium alginate, an anionic polymer, to form an interpol...

The urgent need for new green and sustainable models is ground the current demand of innovative renewable resource based pharmaceutical products. We propose a Rojo Duro skin onion extract loaded poloxamer/chitosan spray mucoadhesive thermogel aimed at solving limitations in oral mucosits treatment. Being among main side effects radio- chemotherapy, effective treatment buccal lesions still repre...

In the present study, thiol-functionalization of tamarind seed polysaccharide was carried out by esterification with thioglycolic acid. Thiol-functionalization was confirmed by SH stretch in Fourier-transformed infra-red spectra at 2586 cm(-1). It was found to possess 104.5 mM of thiol groups per gram. The results of differential scanning calorimetry and X-ray diffraction study indicate increas...

A new drug delivery system for H2 receptor antagonist Ranitidine hydrochloride, was developed utilizing both the concepts of adhesiveness and of flotation, in order to obtain a unique drug delivery system which could remain in the stomach for a much longer period of tim Floating-Mucoadesive tablets of Ranitidine hydrochloride were developed to prolong its release and improve bioavailability. Ra...

The vagina has been studied as a favorable site for local and systemic delivery of drugs for female-related conditions. There are a large number of vaginal medications on the market and most of them require frequent application due to their short vaginal residence time. A prolonged vaginal residence time of formulations is therefore a key parameter for improved therapeutic efficacy. Promising a...

Ketoconazole topical is an antifungal medication. Ketoconazole topical prevents fungus from growing on your skin. The aim of the present investigation was to design and formulate an appropriate microspheres loaded gel (MLG), and explore the parameters affecting the morphology and other characteristics of the resultant products employing scanning electron microscopy (SEM). Microspheres loaded to...

The scope of the present study is to develop a prolonged the delivery of the active drug in the oral cavity using a suitable carrier such as in situ gels which can effectively deliver the drug for an extended duration of time hence not only reduce the systemic side effects but also improve the therapeutic efficacy, patient compliance. Local drug delivery systems are better suitable for antifung...

Among novel drug delivery systems, Buccal mucoadhesive systems have attracted great attention in recent years due to their ability to adhere and remain on the oral mucosa and to release their drug content gradually. Mucoadhesion may be defined as the process where polymers attach to biological substrate or a synthetic or natural macromolecule, to mucus or an epithelial surface. Buccal mucoadhes...

The purpose of present investigation was to develop and optimize bucco mucoadhesive bilayered tablets of Propranolol hydrochloride (PrHCL) using the bioadhesive polymers hydroxyl propyl methyl cellulose (HPMC K4M), xanthan gum (XG) and acrypol 934P (AL-P) individually and in combination along with ethyl cellulose (EC) as an impermeable backing layer. The 3 full factorial design was employed by ...

the purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934p as mucoadhesive polymer and ethyl cellulose as carrier ...