BACKGROUND Multi-drug resistant tuberculosis (MDR TB) is a major health challenge in India that is gaining increasing public attention, but the implications of India's evolving MDR TB epidemic are poorly understood. As India's MDR TB epidemic is transitioning from a treatment-generated to transmission-generated epidemic, we sought to evaluate the potential effectiveness of the following two dis...

Tyrosine kinases (TKs) play an important role in pathways that regulate cancer cell proliferation, apoptosis, angiogenesis and metastasis. Aberrant activity of TKs has been implicated in several types of cancers. In recent years, tyrosine kinase inhibitors (TKIs) have been developed to interfere with the activity of deregulated kinases. These TKIs are remarkably effective in the treatment of va...

Nigeria has an emerging problem with multidrug-resistant tuberculosis (MDR-TB). Whole-genome sequencing was used to understand the epidemiology of tuberculosis and genetics of multi-drug resistance among patients from two tertiary referral centers in Southwest Nigeria. In line with previous molecular epidemiology studies, most isolates of Mycobacterium tuberculosis from this dataset belonged to...

multi drug resistance (mdr) is a serious obstacle in the management of breast cancer. therefore, overcoming mdr using novel anticancer agents is a top priority for medicinal chemists. it was found that dihydropyridines lacking calcium antagonistic activity (e.g acridinediones) possess mdr modifier potency. in this study, the capability of four novel acridine-1,8-diones derivatives 3a-d were eva...

BACKGROUND One of the fundamental issues of infectious disease treatment is drug resistance. The aim of the present study was to investigate the first-line anti-tuberculosis drug resistance rates and determine the risk factors related to multidrug resistant mycobacterium tuberculosis. METHODS From March 2011 to September 2012, mycobacterial strains were collected from one hundred fifteen diag...

Multi-drug resistant tuberculosis (MDR-TB) is associated with increased morbidity and mortality compared to drug-sensitive disease. Although MDR-TB is infrequent in Ireland, cases continue to be diagnosed in both Irish and foreign-born people. We conducted a clinical audit of 13 MDR-TB patients treated in two tertiary referral centers, the Mercy Hospital, Cork and St James's Hospital, Dublin be...

Drug-resistant tuberculosis is a public health concern. TB that drug-resistant to rifampin and isoniazid known as MDR-TB, whereas XDR-TB MDR-TB also resistant second-line medicines, such fluoroquinolones (levofloxacin, ofloxacin, moxifloxacin). rifampin-resistant (RR-TB), of which 78 percent had multidrug-resistant (MDR-TB) (MDR-TB). Fluoroquinolones are class broad-spectrum antimicrobials have...

introduction: multi-drug resistant (mdr) p. aeruginosa is constantly increasing and causing severe issues in combatting widely spread health problems. the aim of this study was to assess colistin susceptibility in mdr p. aeruginosa isolates obtained from different infection sites. methods: ninety clinical isolates of p. aeruginosa were collected from different hospitals of the tabriz university...

background: one of the limitations in the treatment of common diseases such as cancer chemotherapy is development of multidrug re sistance (mdr). polymorphisms could alter the expression level of mdr1 gene, which plays an important role in mdr. in this research, the frequency of c3435t, c1236t, and g2677t/a polymorphisms of mdr1 gene was investigated in a large group of population from hamadan ...