Janus kinase 2 (JAK2) is a cytoplasmic protein-tyrosine kinase that catalyzes the transfer of the γ-phosphate group of adenosine triphosphate to the hydroxyl groups of specific tyrosine residues in signal transduction molecules. JAK2 mediates signaling downstream of cytokine receptors after ligand-induced autophosphorylation of both receptor and enzyme. The main downstream effectors of JAK2 are...

MOTIVATION Omics Pipe (http://sulab.scripps.edu/omicspipe) is a computational framework that automates multi-omics data analysis pipelines on high performance compute clusters and in the cloud. It supports best practice published pipelines for RNA-seq, miRNA-seq, Exome-seq, Whole-Genome sequencing, ChIP-seq analyses and automatic processing of data from The Cancer Genome Atlas (TCGA). Omics Pip...

In this paper, the superelastic shape memory alloy (SMA) slit damper system as an alternative design approach for steel structures is intended to be evaluated with respect to inelastic behavior simulated by refined finite element (FE) analyses. Although the steel slit dampers conventionally used for aseismic design are able to dissipate a considerable amount of energy generated by the plastic y...

We present a time-dependent multi-zone code for simulating the variability of Synchrotron-Self Compton (SSC) sources. The code adopts a multi-zone pipe geometry for the emission region, appropriate for simulating emission from a standing or propagating shock in a collimated jet. Variations in the injection of relativistic electrons in the inlet propagate along the length of the pipe cooling rad...

In female MPD patients, sexual intercourse and pregnancy are experiences of which only one or a few alter personalities may he aware. 7ien the host personality i.s is amneslir for these dissociated functions, severe complications may arise both for the affected woman and those around her. When the amnesia is lifted, the personalities involved may experience pregnancy and delivery as traumatic, ...

in this paper, the optimal location and characteristics of tadas dampers in moment resisting steel structures, considering the application of minimum number of tadas dampers in a building as an objective function and the restriction for destruction of main members is studied. genetic algorithm in first generation randomly produces different chromosomes representing unique tadas dampers distribu...

The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively. The hamster Lec35 gene is shown to encode the previously identified cDNA SL15, which corrects the Lec3...

“Mapping the Underworld” is a large multi-disciplinary, multi-university research programme taking place in the UK, which aims to revolutionize the way we undertake streetworks. Within this programme, a number of vibration-based techniques for remotely detecting and locating buried pipes have been developed. Relying either on the direct excitation of a pipe as it comes up to the surface or exci...

Multiple personality disorder (MPD) has at times been confused with both schizophrenia (SCHIZ) and borderlinepersonality disorder (BPD). In this study, 38patients withDSM-III-R diagnosis ofMPD (N = 16), SCHIZ (N = 11), or BPD (N = 11) were evaluated with a battery of structured interviews (SCID, DDIS) and psychometric tests (MMPI, MCMI, DES) in order to define distinguishing features among the ...

Endoscopic placement of plastic stents to treat stricture of the main pancreatic duct (MPD) due to chronic pancreatitis has been widely accepted [1]. In spite of the improvement of endoscopic skills and devices, proximal migration is one of the most troubling problems. Here we describe a new technique for removing a pancreatic plastic stent (PPS) from the MPD. We present a case of a 47-year-old...