This Cross-sectional observational study was conducted to determine the clinical profile of drug-resistant tuberculosis in children. Patients were classified as monoresistant TB, polyresistant TB, multidrug resistant (MDR)-TB and extensively drug resistant (XDR - TB). We coined a term called as Partial XDR-TB when isolates of Mycobacterium tuberculosis were confirmed to be resistant in vitro to...

Kazakhstan is one of the 14 countries with a high rate of morbidity due to multidrug-resistant tuberculosis (MDR TB) in WHO European region. The aim of our study was to characterize mutations associated with drug resistance to rifampicin and isoniazid in Mycobacterium tuberculosis isolates from Kazakhstan. M. tuberculosis strains were isolated from TB patients in different regions of Kazakhstan...

The emergence of multidrug-resistant tuberculosis underscores the need for low-cost, rapid methods to determine the susceptibility of Mycobacterium tuberculosis to antibiotics. A new, rapid, easily read, and inexpensive colorimetric method with a tetrazolium indicator performs this determination as quickly and accurately as the more expensive Alamar Blue technique.

Co-trimoxazole (SXT), a combination of sulfamethoxazole (SMX) and trimethoprim has shown in vitro activity against Mycobacterium tuberculosis. However, the pharmacokinetic (PK) and pharmacodynamic (PD) parameters of SXT in multidrug-resistant (MDR) tuberculosis (TB) are so far lacking. Therefore we evaluated the PK and drug susceptibility along with its tolerability during treatment. Based on d...

Multi-drug resistant (MDR) tuberculosis is defined as disease caused by Mycobacterium tuberculosis with resistance to at least two anti-tubercular drugs Isoniazid and Rifampicin. Recent surveillance data have revealed that prevalence of the drug resistant tuberculosis has risen to the highest rate ever recorded in the history. Drug resistant tuberculosis generally arises through the selection o...

Tuberculosis is an opportunistic infection, the minute it finds an immunocompromised host, it flourishes. The risk of tuberculosis is much higher in patients who are human immunodeficiency virus (HIV) positive. Drug resistance among microbes is testimony to their adaptive skills. In Mycobacterium Tuberculosis the resistance occurs due to random, single step, spontaneous mutation and is invariab...

Abstract: Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis. 10 million people suffer from TB Every year. Although preventable and treatable disease, 1.5 die every year due to TB. Alternative treatments continue be pursued, treatment with the latest drugs that are continuously being encouraged. Black cumin (Nigella sativa) seed contains essential oils act...

Drug-resistant tuberculosis (TB) presents a major challenge to global TB control. To gain a better understanding of drug-resistant TB epidemiology in Malatya, Turkey, we conducted the present study using 397 Mycobacterium tuberculosis clinical isolates collected from Malatya, Turkey, in recent years (2000-2007). Resistance to any anti-TB drug was found in 29% (114 of 397) of the study isolates,...

Multidrug resistant Mycobacterium tuberculosis (MDR-TB) is of great public health importance worldwide. This three month laboratory- based study (1st September-30th November, 2011) was carried out at the TB laboratories of the University College Hospital, Ibadan, Nigeria to determine the magnitude of MDR-TB using molecular based GenoType MTBDRplus 96 assay. Two sputum samples were collected fro...