Activated protein C (APC) is a natural anticoagulant that plays a pivotal role in coagulation homeostasis. Severe inherited or acquired deficiency results in a clinical syndrome called purpura fulminans. In addition, APC also appears to have potent cytokine-modifying properties and is protective in animal models of sepsis. The dual functional properties of APC are particularly relevant to sever...

The lack of effective treatments for heart failure with preserved ejection fraction represents a large and growing unmet need in cardiology today. A critical obstacle to therapeutic innovation in heart failure with preserved ejection fraction has been the absence of animal models that accurately recapitulate the complexities of the human disease. Here, we propose that more comprehensive multior...

A 29-year-old patient with patent foramen ovale (PFO) and arteriovenous-malformation developed Eisenmenger’s syndrome with subsequent multiorgan failure. Percutaneous veno-arterial extracorporal life support was established via the groin (Fig. 1). Transoesophageal echocardiography revealed a malposition of the venous cannula in the PFO (Fig. 2). The position of the cannula was corrected immedia...

Activated protein C (APC) is a natural anticoagulant that plays a pivotal role in coagulation homeostasis. Severe inherited or acquired deficiency results in a clinical syndrome called purpura fulminans. In addition, APC also appears to have potent cytokine-modifying properties and is protective in animal models of sepsis. The dual functional properties of APC are particularly relevant to sever...