Introduction. Clear cell basal cell carcinoma (BCC) is an uncommon and unusual variant of BCC, which is characterized by a variable component of clear cells. The pathogenesis of this histological variant and its clinical significance has not been clarified. Differentiation of this uncommon variant of BCC from other clear cell tumors is important for the treatment. Case Presentation. A 65-year-o...

Monoclonal antibodies that block immune regulatory proteins such as programmed death-1 (PD-1) have demonstrated remarkable efficacy in controlling the growth of multiple tumor types. Unresectable or metastatic basal cell carcinoma, however, has largely gone untested. Because PD-Ligand-1 (PD-L1) expression in other tumor types has been associated with response to anti-PD-1, we investigated the e...

Neoplastic lesions of the skin are among the most common human malignancies. They originate from different skin tissues and structures such as:  epidermis  skin appendages (hair follicles, sebaceous glands, eccrine sweat glands, apocrine sweat glands)  pigment cells (melanocytes)  mesenchymal structures (fibrous tissue, fatty tissue, blood and lymphatic vessels, muscles)  nerves and APUD c...

nodules that reside within the dermis and frequently demonstrate epidermal attachment. Multifocal lobules of varying size and shape exhibit peripheral palisading and central haphazard array of cells.The entire tumor demonstrates an expansile growth pattern. Cystic degeneration or central necrosis may be prominent. Although similar to the nodular variant, micronodular basal cell carcinoma is com...

8. Makker R, Ramesh V. On the diagnosis of facial granulomatous dermatoses of obscure origin. International Journal of Dermatology. 2005;44:606-9. 9. Helm KF, Menz J, Gibson LE, Dicken CH. A clinical and histopathologic study of granulomatous rosacea. J Am Acad Dermatol. 1991;25:1038-43. 10. Cribier B, Lieber-Mbomeyo A, Lipsker D. Clinical and histological study of a case of facial Afro-Caribbe...

Basal cell carcinoma is the most common skin cancer in the Caucasian population. The cancer arises in sun exposed areas of the skin. The incidence of morbidity is high and it is still growing. The metastatic rate is low, but the enlarging tumor may cause severe tissue disfigurement and a poor cosmetic outcome. The diagnosis is usually clinical but there are many subtypes of this carcinoma and c...