نتایج جستجو برای: myelin oligodendrocyte glycoprotein
تعداد نتایج: 105655 فیلتر نتایج به سال:
multiple sclerosis (ms) is a progressive and autoimmune neurodegenerative disease of the central nervous system (cns). this disease is recognized through symptoms like inflammation, demyelination and the destruction of neurological actions. experimental allergic encephalomyelitis (eae) is a widely accepted animal model for ms. eae is created in animals by injecting the tissue of myelin basic pr...
Abstract Multiple Sclerosis is a demyelinating autoimmune disease brought on by self-reactive, myelin-specific T effector cells. Immunosuppressants are the most utilized tool to combat progression; however, they bring unwanted side effects. We have previously published novel gene immunotherapy that uses an adeno-associated virus (AAV) containing full sequence of myelin oligodendrocyte glycoprot...
OBJECTIVE To evaluate antibodies to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and control individuals. DESIGN Prospective case-control series. SETTING Academic referral center. PATIENTS Twenty-six controls with noninflammatory neurologic disease and 35 patients with MS donated serum and CSF for recombinant...
OBJECTIVES To investigate the differences of clinical features, cerebrospinal fluid (CSF), MRI findings and response to steroid therapies between patients with optic neuritis (ON) who have myelin oligodendrocyte glycoprotein (MOG) antibodies and those who have seronegative ON. SETTING We recruited participants in the department of neurology and ophthalmology in our hospital in Japan. METHOD...
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an immune-mediated inflammatory central nervous system (CNS) that has been gradually recognized in recent years and currently considered as a distinct entity distinguished from multiple sclerosis neuromyelitis optica spectrum disorder. Lately, the new diagnostic criteria for MOGAD proposed by International Panel we...
Myelin oligodendrocyte glycoprotein (MOG)-associated disease is an autoimmune of the central nervous system, associated with presence immunoglobulin G serum antibodies against MOG. Recent data have allowed characterization clinical spectrum MOG-associated disease, which now considered a new entity, distinct from multiple sclerosis and neuromyelitis optica disorders. Optic neuritis most common p...
The inability of CNS axons to regenerate after traumatic spinal cord injury is due, in part, to the inhibitory effects of myelin. The three major previously identified constituents of this activity (Nogo, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein) were isolated based on their potent inhibition of axon outgrowth in vitro. All three myelin components transduce their ...
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