Abstract In peripheral nerves, Schwann cells form myelin and provide trophic support to axons. We previously showed that the mitochondrial protein prohibitin 2 can localize axon-Schwann-cell interface is required for developmental myelination. Whether homologous 1 has a similar role, whether prohibitins also play important roles in cell mitochondria unknown. Here, we show deletion of minimally ...

Organ-specific highly basic protein derived from guinea pig central nervous system myelin was found to be electrophoretically heterogeneous. It did not appear to be heterogeneous with respect to molecular size. The electrophoretic technique used to demonstrate this heterogeneity was capable of resolving mixtures of closely related basic proteins whether they were present in crude extracts or in...

Diese Dissertation wurde selbständig, ohne unerlaubte Hilfe erarbeitet. 3.3.3 mb eGFP under the control of claudin k promoter specifically and strongly labels the processes of Summary 1 1 SUMMARY Myelination is a key step in vertebrate evolution: oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS) tightly wrap their cytoplasmic processes...

To probe the effects of possible inhibitors or enhancers of in vivo myelination, we have modified a technique widely used in studies of the developing neuromuscular system that involves incorporation of test compounds into a silicon rubber solution, which solidifies on contact with air. U-shaped rubber implants are inserted around the sciatic nerve of 1-day-old rats and left in place for 24-48 ...

The goal of this study was to show that myelin and axons in cortical gray matter are damaged in Alzheimer's disease (AD) brain. Superior temporal gyrus gray matter of AD patients (9 male, 14 female) was compared to cognitively normal controls (8 male, 7 female). Myelin basic protein (MBP) and a degraded myelin basic protein complex (dMBP) were quantified by Western blot. Brain sections were imm...

according to the well-known classification of dyck, inherited peripheral neuropathies can be categorized as hereditary motor and sensory neuropathies (hmsn) or charcot – marie – tooth (cmt) disease, hereditary motor neuropathies (hmn), and hereditary sensory neuropathies (hsn). cmt is a clinically and genetically heterogeneous group of motor and sensory neuropathies, and is the most common inhe...

The cellular prion protein (PrP) is essential to the long-term maintenance of myelin sheaths in peripheral nerves. PrP activates adhesion G-protein coupled receptor Adgrg6 on Schwann cells and initiates a pro-myelination cascade molecular signals. Because crucial for development regeneration after nerve injury, we investigated role repair. We performed experimental sciatic crush injuries co-iso...

Formation of the CNS white matter is developmentally tightly regulated, but the molecules and mechanisms of myelination control in the postnatal CNS are poorly understood. Here, we show that myelin growth is controlled by fibroblast growth factor (FGF) signaling, originally identified as a proliferative signal for oligodendrocyte precursor cells (OPCs) in vitro. We created two lines of mice lac...

Altered axon-Schwann cell interactions in PNS myelin-deficient Trembler mice result in changed axonal transport rates, neurofilament and microtubule-associated protein phosphorylation, neurofilament density, and microtubule stability. To determine whether PNS and CNS myelination have equivalent effects on axons, neurofilaments, and microtubules in CNS, myelin-deficient shiverer axons were exami...