Silent myocardial ischemia is typically defined as objective evidence of myocardial ischemia in patients without subjective ischemia symptoms. Currently, coronary artery angiography is the gold standard for diagnosis of asymptomatic coronary artery disease (CAD). Computed tomography coronary angiography (CTCA) can visually demonstrate the morphology, trend and extent of coronary stenosis and is...

bilateral diffuse intense breast uptake was noted in a 40 year old female who was evaluated with tc-99m sestamibi (mibi) myocardial perfusion scan for possible ischemia. she was breast feeding her 1.5 year old child. the intense uptake in the breasts was superimposed on the apical and anteroapical regions of the myocardium and caused interpretation problem. we recommend considering tc-99m mibi ...

Clinicians often fail to detect intraoperative ischemic electrocardiographic (ECG) changes when viewing oscilloscopes. Automated ST-segment monitors promise to increase the detection of such ECG changes. We investigated the capacity of two commercially available ST-segment monitors to detect intraoperative myocardial ischemia in patients at high risk for developing intraoperative myocardial isc...

Anti-ischemic drug therapy during anesthesia is indicated whenever evidence of myocardial ischemia exists. The treatment of ischemia during anesthesia is complicated by the ongoing stress of surgery, blood loss, concurrent organ ischemia, and the patient’s inability to interact with the anesthesiologist. Nonetheless, the fundamental principles of treatment remain the same as in the unanesthetiz...

Sbarouni et al. (1) reported on “Ischemia-Modified Albumin [IMA] in Relation to Exercise Stress Testing [EST]” in a previous issue of the Journal. Although the investigators found significant differences in the IMA values at baseline, peak exercise, and after EST, there was no relation between the IMA changes and the result of the EST. The researchers stated that changes in IMA levels do not re...

The protective effects of ilexsaponin A on ischemia-reperfusion-induced myocardial injury were investigated. Myocardial ischemia/reperfusion model was established in male Sprague-Dawley rats. Myocardial injury was evaluated by TTC staining and myocardial marker enzyme leakage. The in vitro protective potential of Ilexsaponin A was assessed on hypoxia/reoxygenation cellular model in neonatal rat...

Inhalational anesthetic-induced preconditioning (APC) has been shown to reduce infarct size and attenuate contractile dysfunction caused by myocardial ischemia. Only a few studies have reported the effects of APC on arrhythmias during myocardial ischemia-reperfusion injury, focusing exclusively on reperfusion. Accordingly, the aim of the present study was to examine the influence of APC on vent...

Clinical and experimental evidence has shown that myocardial ischemia activates cardiac spinal afferents that mediate sympathoexcitatory reflex responses. During myocardial ischemia, thromboxane A2 (TxA2) is released in large quantities by activated platelets in the coronary circulation of patients with coronary artery disease. We hypothesized that endogenous TxA2 contributes to sympathoexcitat...

OBJECTIVE Peripheral vascular surgery involving limb ischemia/reperfusion is associated with tumor necrosis factor-alpha production and an increased risk of cardiac complications. The objective of this study was to investigate the role of tumor necrosis factor-alpha in myocardial apoptosis and dysfunction following hindlimb ischemia/reperfusion. DESIGN Randomized perspective animal study. S...