Objective: Tissue Doppler Imaging (TDI) is commonly used to evaluate regional ventricular contraction 26 properties through the analysis of myocardial strain. During the clinical examination, a set of strain signals is 27 acquired concurrently at different locations. However, the joint interpretation of these signals remains 28 difficult. This paper proposes a model-based approach in order to a...

Introduction: Ventricular remodeling is the process by which ventricular size, shape and function are regulated by mechanical, neurohormonal and genetic factors.1 Remodeling may be physiological and adaptive during normal growth or pathological due to acute myocardial infraction (AMI), cardiomyopathy, hypertension or valvular heat disease. This article will re view left ventricular (LV) remodel...

the aim of present study was to investigate whether food restriction combined with exercise training could attenuate the oxidative stress and promote angiogenesis in a rat model of heart failure. 50 male wistar rats weighing 250-300 g were randomly divided into 5 groups including: 1) sham; they were fed ad libitum food, n=10. 2) heart failure group; 3) exercise group; they run on a treadmill 5 ...

Mechanical complications after myocardial infarction are uncommon with advances in medical reperfusion strategies. However, such strategies are associated with bleeding complications which typically contraindicate surgical management. We describe a patient with a post-infarction ventricular septal defect and an intraventricular hemorrhage following thrombolytic therapy for an acute myocardial i...

Altered regional mechanical myocardial performance is an early, sensitive marker of myocardial ischemia, and can be estimated in man with reasonable accuracy. Identification, localization and quantification of abnormalities in mechanical performance can be used to predict the presence of coronary artery disease. Testing techniques that have little or no effect on diagnostic efficiency must be r...

Our previous study demonstrated that periostin, an extracellular matrix protein, plays an important role in left ventricular remodeling through the inhibition of cell-cell interactions. Because the gene regulation of periostin has not yet been examined, we focused on the effects of angiotensin (Ang) II and mechanical stretch, because Ang II and mechanical stretch are related to cardiac remodeli...

Background Despite different aetiology of myocardial damage in dilated cardiomyopathy (DCM) and ischaemic cardiomyopathy (IHD), cardiac remodelling occurs in both, culminating in the end result of a dilated left ventricle with impaired function. Cardiac remodelling is a complex process in which numerous cellular, mechanical and flow processes become deranged. Insights into changes of multidimen...

BACKGROUND Brief myocardial ischaemia has been demonstrated to result in mechanical and coronary endothelial dysfunction, in which calcium may play a role. We examined whether the mechanical and vascular responses to calcium are altered in postischaemic, reperfused myocardium. METHODS Regional myocardial oxygen consumption (MVO2), mechanical function and coronary blood flow (CBF) in response ...