Myocarditis is defined as inflammation of the myocardium, and it presents with different clinical pictures, its diagnosis has some difficulties. The prognosis myocarditis aetiology-dependent, treatment fundemantally supportive except for “endometrial biopsy proven” cases which requires spesific therapies including immunomodulators intravenous immunoglobulins. SARS-CoV-2 affects cardiovascular s...

BACKGROUND Fatal clozapine-induced myocarditis has not been investigated systematically. We describe the clinical course of 10 fatal cases of myocarditis with clozapine and identify factors associated with fatality. METHODS Cases of myocarditis were documented from the patient's medical records and fatal cases also from autopsy reports. RESULTS The fatal cases of myocarditis occurred 1996-2...

BACKGROUND The role of β-adrenergic stimulation on viral myocarditis has been investigated in animal models of viral myocarditis. Excess stimulation of β-adrenergic receptors by catecholamines causes phosphorylation/activation of cAMP response element binding protein (CREB) by the cAMP signaling pathway. CREB as an important regulator of gene expression mediates the cardiovascular remodeling pr...

OBJECTIVES To examine the relation between antipsychotic drugs and myocarditis and cardiomyopathy. DESIGN Data mining using bayesian statistics implemented in a neural network architecture. SETTING International database on adverse drug reactions run by the World Health Organization programme for international drug monitoring. MAIN OUTCOME MEASURES Reports mentioning antipsychotic drugs, ...

Viral myocarditis is one of the major causes of congestive heart failure and dilated cardiomyopathy. Recent reports have demonstrated an essential role of cytokines, like interleukin-13 (IL-13), in the pathogenesis of viral myocarditis, while the underlying mechanisms remain poorly defined. Here, using a coxsackie virus B3 (CVB3)-infection model in BALB/C mice, we showed that IL-13 protected mo...

AIMS The clinical outcome of severe acute myocarditis patients with cardiogenic shock who require circulatory support devices is not well known. We studied the survival and clinical courses of patients with fulminant myocarditis supported by percutaneous extracorporeal membrane oxygenation (ECMO) and compared them with those of patients with acute non-fulminant myocarditis. METHODS AND RESULT...

West Nile virus (WNV) myocarditis has been documented pathologically in birds and mammals but has rarely been reported in human clinical syndromes. We describe myocarditis associated with WNV.

Introduction Myocarditis is a frequent cardiac disease occurring in all ages that is difficult to diagnose. However, new procedures such as cardiac magnetic resonance imaging (CMR) and biventricular endomyocardial biopsy with histological, immunohistochemical and microbiological work-up have revolutionized the diagnosis of myocarditis in the last years. Nevertheless, the long-term mortality aft...

A 72-year-old female with late onset systemic lupus erythematosus (SLE) was admitted with chest pain and dyspnoea, and was submitted to investigation by echocardiogram, cardiovascular magnetic resonance(CMR) and serology panel. Morphological and functional studies of the heart revealed conspicuous inflammatory signs and moderate effusion compatible with myocarditis and pericarditis. Myocarditis...

BACKGROUND The pathologic diagnosis of isolated myocarditis without pericardial involvement is uncommonly encountered in systemic onset Juvenile Idiopathic Arthritis (soJIA). CASE An eleven year-old boy with soJIA died suddenly while being treated with the interleukin 1 (IL-1) receptor inhibitor, anakinra. His autopsy revealed an enlarged heart and microscopic findings were consistent with my...