Skeletal muscles play an active role in regulating the metabolic homeostasis through their ability for relating to adipose tissue and endocrine hormones. Contraction of the skeletal muscle leads to increased release of several myokines, such as irisin, which is able to interact with the adipose tissue. Physical activity promotes the irisin mechanism by augmenting the peroxisomes (PGC1-α) in the...

The purpose of this study was to investigate the effects high-intensity interval training (HIIT) and moderate-intensity continuous (MICT) on skeletal muscle in Apolipoprotein E knockout (ApoE KO) wild-type (WT) C57BL/6J mice. ApoE KO mice fed with a high-fat diet were randomly allocated into: Control group without exercise (ApoE−/− CON), HIIT HIIT), MICT MICT). Exercise endurance, blood lipid p...

Introduction Irisin, a newly discovered myokine, has been reported for its role in coronary artery disease (CAD), which is major cause of mortality worldwide. Atherosclerosis the primary CAD. Irisin to reduce atherosclerosis by improving endothelial function and inhibiting inflammation via iNOS/NF-κB pathways. We sought investigate relationship between serum irisin levels severity CAD that conf...