نتایج جستجو برای: n acetyl d glucosamine
تعداد نتایج: 1441751 فیلتر نتایج به سال:
Mucopolysaccharidosis type IIIB is a devastating neurological disease caused by lack of the lysosomal enzyme, α-N-acetylglucosaminidase (NAGLU), leading to toxic accumulation heparan sulfate. Herein we explored pharmacological chaperone approach enhance residual activity NAGLU in patient fibroblasts. Capitalizing on three-dimensional structures two modest homoiminosugar-based inhibitors complex...
Short-chain fatty acid (SCFA)-carbohydrate hybrid molecules that target both histone deacetylation and glycosylation pathways to achieve sugar-dependent activity against cancer cells are described in this article. Specifically, n-butyrate esters of N-acetyl-D-mannosamine (But4ManNAc, 1) induced apoptosis, whereas corresponding N-acetyl-D-glucosamine (But4GlcNAc, 2), D-mannose (But5Man, 3), or g...
N-Acetyl-d-glucosamine-6-phosphate Deacetylase: Substrate Activation via a Single Divalent Metal Ion
The genetic relationships between the multiple variants of mucolipidosis II (I-cell disease) and mucolipidosis III (pseudo-Hurler polydystrophy) were investigated with a sensitive genetic complementation analysis procedure. These clinically distinct disorders have defects in the synthesis of a recognition marker necessary for the intracellular transport of acid hydrolases into lysosomes. Both d...
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