Background. Tolerance to the effects of organic nitrates develops rapidly during continuous exposure to these drugs; its main mechanism seems to be an intracellular sulfhydryl group depletion. However, the relative susceptibility to the development of nitroglycerin tolerance of the arterial or venous circulation in humans is still a matter of dispute. Methods and Results. Twenty patients with c...

n engl j med 355;14 www.nejm.org october 5, 2006 1500 large thrombus burden. Indeed, a recent study comparing clinical and procedural characteristics among hospitals, mostly regarding elective percutaneous coronary intervention, invariably reported a contrast volume of more than 200 ml.5 Finally, the difference in the primary end point and the other clinical end points between the two N-acetylc...