The influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated {PEG [poly(ethylene glycol)]-conjugated} haemoglobin has been investigated. The sites and the extent of PEGylation of haemoglobin by reductive alkylation are not influenced by the presence of an alphaalpha-fumaryl cross-link at Lys-99(alpha). The propylated hexaPEGylated cross-linked ...

Sucrose phosphate synthase (SPS) berperan penting untuk biosintesis sukrosa pada tanaman. SPS tanaman dibagi menjadi beberapa domain diantaranya bagian domian N-terminal, C-terminal, dan glycosyltransferase (GT). Namun, fungsi N-terminal C-terminal masih belum jelas. Oleh karenanya, dilakukan studi karakterisasi masing-masing melalui penghilangan (∆N), (∆C), kedua tersebut (∆NC). Mutan ∆N, ∆C, ...

The limited stability of proteins in vitro and in vivo reduces their conversion into effective biopharmaceuticals. To overcome this problem several strategies can be exploited, as the conjugation of the protein of interest with polyethylene glycol, in most cases, improves its stability and pharmacokinetics. In this work, we report a biophysical characterization of the non-pegylated and of two d...

in order to design and manufacturing some postharvest equipment, determination of some hydrodynamic properties of crops are necessary. the quality of products in global and local markets can be increased by applying these properties and receive economical benefits. for these purpose, two local varieties of apples in the east azerbaijan province, iran(asheghi and gare yapraq)were selected.ashegh...

PEGylation is a well-established technique utilized to overcome the problems related to the therapeutic applications of peptides and proteins. Reasons for the PEGylation of these biological macromolecules include reducing immunogenicity, proteolytic degradation and rapid clearance from blood circulation. Octreotide is an octapeptide analogue of naturally-occurred somatostatin. This peptide has ...

PEGylation is a well-established technique utilized to overcome the problems related to the therapeutic applications of peptides and proteins. Reasons for the PEGylation of these biological macromolecules include reducing immunogenicity, proteolytic degradation and rapid clearance from blood circulation. Octreotide is an octapeptide analogue of naturally-occurred somatostatin. This peptide has ...