The structure of a new antifungal antibiotic, mycoversilin, produced by Aspergillus versicolor (N5)17 was determined as I by various spectroscopic and chemical methods. Mycoversilin is a unique polynuclear aromatic compound having two methyl and six hydroxyl groups and two ether linkages. The acetyl derivative prepared was found to have no antifungal property.

The cholinergic anti-inflammatory pathway is one of the putative biochemical pathways that link diabetes with Alzheimer disease. Hence, we aimed to verify the potential antidiabetic effect of galantamine, unveil the possible mechanisms and evaluate its interaction with vildagliptin. The n5-STZ rat model was adopted and the diabetic animals were treated with galantamine and/or vildagliptin for 4...

Escherichia coli PurK, a dimeric N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) synthetase, catalyzes the conversion of 5-aminoimidazole ribonucleotide (AIR), ATP, and bicarbonate to N5-CAIR, ADP, and Pi. Crystallization of both a sulfate-liganded and the MgADP-liganded E. coli PurK has resulted in structures at 2.1 and 2.5 A resolution, respectively. PurK belongs to the ATP grasp superfamil...

There are 9 serotypes of neuraminidase (NA) from influenza A virus (N1 to N9), which are classified into two groups based on primary sequences (groups 1 and 2). The structural hallmark of the two groups is the presence or absence of an extra 150-cavity (formed by the 150-loop) in the active site. Thus far, structures of NAs from 6 out of the 9 serotypes have been solved. Here, we solved the N5 ...

An electrooptic effect in the blue phase of the cholesteric mixture S811- and the nematic mixture N5 is reported. To demonstrate this effect ac voltages (f = 1000 Hz) between 0 and 150 V were applied. Wavelength shifts of 70 nm were obtained.

4 We propose a new algorithm for envelope estimation, along with a new √ n5 consistent method for computing starting values. The new algorithm, which does not 6 require optimization over a Grassmannian, is shown by simulation to be much faster 7 and typically more accurate than the best existing algorithm proposed by Cook and 8 Zhang [7]. 9

We present an algorithm to find two non-linear polynomials for the Number Field Sieve integer factorization method. This algorithm extends Montgomery’s “two quadratics” method; for degree 3, it gives two skewed polynomials with resultant O(N5/4), which improves on Williams O(N4/3) result [12].