نتایج جستجو برای: nanosuspension
تعداد نتایج: 314 فیلتر نتایج به سال:
The production of an intramuscular (IM) injection of natural progesterone would provide a safer solution than using semi synthetic progesterone. However, disadvantages such as low solubility and a short half life prevent the use of natural progesterone. In this study, we formulated a sustained release form of natural progesterone to be given as IM injection. A progesterone nanosuspension (PNS) ...
Mucoadhesive nanosuspension of ciprofloxacin was designed in order to improve the solubility, bioavailability and efficacy for the treatment of typhoid fever. The identity and purity of drug was established. The compatibility of drug with various excipients was ascertained by FTIR techniques, which indicated no interaction between the drug and excipients. Four different formulations were prepar...
Nanoparticles of a bicalutamide nanosuspension were imaged using Atomic Force Microscopy (AFM) to gain some insight into particle size and aggregation. Particles of bicalutamide in a PVP-stabilised suspension were imaged and the data analyzed. The particles were observed to be uniform in size at down to 160 nm in diameter although some larger aggregates were observed. Sample roughness was analy...
Poorly water-soluble drugs, such as phenylephrine, offer challenging problems for buccal drug delivery. In order to overcome these problems, particle size reduction (to the nanometer range) and cyclodextrin complexation were investigated for permeability enhancement. The apparent solubility in water and the buccal permeation of the original phenylephrine coarse powder, a phenylephrine-cyclodext...
Poorly water-soluble drugs such as nitrendipine (~2.0 μg/ml at 37C in water) offer challenging problems in drug formulation as poor solubility is generally associated to poor dissolution characteristics and thus to poor oral bioavailability. To enhance these characteristics, we prepared and evaluated nitrendipine nanosuspension using the nanoprecipitation technique. The important process parame...
For nearly a century, aluminum salts have been the most widely used vaccine adjuvant formulation, and have thus established a history of safety and efficacy. Nevertheless, for extremely challenging disease targets such as tuberculosis or HIV, the adjuvant activity of aluminum salts may not be potent enough to achieve protective efficacy. Adsorption of TLR ligands to aluminum salts facilitates e...
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