The Cu(II) atom in the title compound, [Cu(C16H10ClN2O)2], is located on an inversion center and is tetra-coordinated by two N and two O atoms from two bidentate 1-[(E)-(2-chloro-phen-yl)diazen-yl]naphthalen-2-olate ligands, forming a square-planar complex. In the crystal, mol-ecules are linked via weak C-H⋯O and C-H⋯Cl hydrogen bonds, forming chains propagating along [010]. There are also π-π ...

In the mononuclear title complex, [CuI(C2H3N)(C26H24N2)], the CuI ion has a distorted tetra-hedral coordination environment, defined by two N atoms of the chelating 2-(naphthalen-1-yl)-6-[(2,4,6-tri-methyl-phen-yl)imino]-pyridine ligand, one N atom of an aceto-nitrile ligand and one iodide ligand. Within the complex, there are weak intra-molecular C-H⋯N hydrogen bonds, while weak inter-molecula...

We report the conformational analysis of a series of 3-hydroxy-N'-((naphthalen-2-yl)methylene)naphthalene-2-carbohydrazides. This class of compounds has recently been reported as androgen receptor (AR)-coactivator disruptors for potential application in prostate cancer therapy. Definition of the E/Z isomerism around the imine linker group (hydrazide) is significant from a mechanistic point of v...

In the title compound, [Ni(C(12)H(9)O(2))(2)(C(7)H(6)N(2))(2)]·H(2)O, The Ni(II) cation is located on a twofold rotation axis and is six-coordinated in a distorted NiN(2)O(4) octa-hedral geometry. The asymmetric unit consists of a nickel(II) ion, one 2-(naphthalen-1-yl)acetate anion, a neutral benzotriazole ligand and one half of a lattice water mol-ecule. The crystal packing is stabilized by O...

The title compounds were prepared by brominating 1-acetylnaphthalene in chloroform followed by condensation with substituted benzaldehyde thiosemicarbazones using ethanol to get 4-naphthalen-1-yl-2-{2-[(substituted phenyl)methylidene]hydrazino}-1,3-thiazoles. These thiazole derivatives were then cyclized to title compounds by reacting with thiomalic acid in dioxane using ZnCl2. All the synthesi...

In the title compound, [Co(C(12)H(9)O(2))(2)(C(4)H(6)N(2))(2)(H(2)O)(2)], the Co(II) ion is located on an inversion centre and displays a distorted octa-hedral coordination geometry. Two O atoms from two water mol-ecules and two carboxyl-ate O atoms from two 2-(naphthalen-1-yl)acetate ligands are in the equatorial plane and two N atoms from two 1-methyl-1H-imidazole ligands are in the axial pos...

In the title compound, C(21)H(23)NO, obtained via a one-pot synthesis, an intra-molecular O-H⋯N hydrogen bond stabilizes the mol-ecular conformation. The dihedral angle between the fused ring system and the phenyl ring is 78.27 (5)°. The crystal packing is characterized by helical chains of mol-ecules linked by C-H⋯O hydrogen bonds.

The asymmetric unit of the title compound, C(16)H(14)N(2), contains two independent mol-ecules in which the dihedral angles between the pyrimidine and naphthaline rings are 38.20 (5) and 39.35 (5)°. Inter-molecular C-H⋯π contacts and π-π stacking inter-actions [centroid-centroid distances = 3.766 (1) and 3.792 (1) Å] are present in the crystal structure.

Dasabuvir [also known as ABT-333 or N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide] is a potent non-nucleoside NS protein 5B polymerase inhibitor of the hepatitis C virus (HCV) and is being developed in combination with paritaprevir/ritonavir and ombitasvir in an oral regimen with three direct-acting antivirals for the treatme...

Products containing naphthalen-1-yl-(1-pentylindol-3-yl) methanone (JWH-018) and naphthalen-1-yl-(1-butylindol-3-yl) methanone (JWH-073) are emerging drugs of abuse. Here, the behavioral effects of JWH-018 and JWH-073 were examined in one behavioral assay selective for cannabinoid agonism, rhesus monkeys (n 4) discriminating -tetrahydrocannabinol ( -THC; 0.1 mg/kg i.v.), and another assay sensi...