BACKGROUND There are widely discrepant views on the respiratory management of infants with spinal muscular atrophy (SMA) type I. Typically, management is palliative. DESIGN A descriptive study of interventions and investigations is reported that were offered to a cohort of 13 children with SMA type I referred to our centre. Interventions and investigations included sleep studies, provision of...

OBJECTIVE Noninvasive positive pressure ventilation (NIPPV) has been shown to decrease the need for invasive mechanical ventilation (MV) in patients presenting with acute respiratory failure (ARF). We conducted a prospective study to assess if NIPPV use, in a developing country, was associated with clinical and physiological improvements. DESIGN Prospective observational study. MATERIALS AN...

Differences between bilevel ventilators used for noninvasive intermittent positive pressure ventilation (NIPPV) have been demonstrated during bench testing. However, there are no clinical studies comparing these machines. The authors have previously shown that the Quantum pressure support ventilator and Sullivan variable positive airway pressure II ST differ in performance during bench testing....

BACKGROUND AND OBJECTIVES There is evidence that new methods of noninvasive ventilation (NIV) support have significantly changed respiratory distress syndrome (RDS) management in preterm infants. Further perspectives for neonatologists involve the assessment of different NIV strategies in terms of availability, effectiveness, and failure. This study evaluates the efficacy of 2 different NIV str...

ATLANTA – Long-term nocturnal use of noninvasive positive pressure ventilation significantly reduced the likelihood of intensive care unit admission in patients with severe stable chronic obstructive pulmonary disease, according to findings from a systematic review of 582 patients in 13 randomized, controlled clinical trials. After 1 year, noninvasive positive pressure ventilation (NIPPV) was a...

We carefully read the article by Yamauchi et al.(1) on using noninvasive positive pressure ventilation (NIPPV) after extubation and congratulate the authors on their study. However, in the last few years, several studies with conflicting results have been published.(1-6) The authors presented the results from a retrospective observational study. Data were collected over a seven-month period to ...

BACKGROUND Long-term non-invasive positive pressure ventilation (NIPPV) might improve the outcomes of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD) with chronic respiratory failure. A study was undertaken to investigate whether nocturnal NIPPV in addition to pulmonary rehabilitation improves health-related quality of life, functional status and gas excha...

Citation Gray A, Goodacre S, Newby DE, Masson M, Sampson F, Nicholl J: Noninvasive ventilation in acute cardiogenic pulmonary edema. N Engl J Med 2008, 359:142-151 [1]. Background Noninvasive ventilation (NIV) (continuous positive airway pressure [CPAP] or noninvasive intermittent positivepressure ventilation [NIPPV]) appears to be of benefi t in the immediate treatment of patients with acute c...

A newborn baby receiving mechanical ventilation was noted to have an extremely variable degree of hypoxia, despite the administration of 100% oxygen. The hypoxia was relieved rapidly when mechanical ventilation was withdrawn.

Cardioventilatory coupling (CVC) is the temporal coherence of respiratory and cardiac rhythms. We have suggested that this coherence is the result of triggering of inspiratory onset by a preceding cardiovascular afferent. One implication of this triggering hypothesis is that coupling should only exist under conditions of spontaneous ventilation and not under conditions where the ventilatory per...