Chronic rhinosinusitis (CRS) is a multifactorial disease; however, the presence of nasal polyposis may be a significant underlying etiological factor affecting the pathophysiology. In the pathophysiology of nasal polyposis, up-regulation of adhesion molecules is induced by interleukin-1 (IL-1) in the vascular endothelium and by IL-8 in epithelial cells and neutrophils. This occurs in addition t...
