Infectious and allergic diseases of the upper airways are among the most common illnesses of all age groups. Numerous guidelines have been issued for the evidence-based treatment of these diseases. Therapy involves local or systemic application of well-characterized pharmacologically active medications such as glucocorticosteroids, antihistamines, leukotriene-receptor antagonists, alpha-adrener...

We conducted a meta-analysis of placebo-controlled laboratory studies of the subjective effects of nicotine. A total of 15 studies (11 with nasal spray, four with intravenous administration) with smokers and six studies (all with nasal spray) with never-smokers were included. Studies of other routes of administration (e.g., smoked tobacco) were not included because of insufficient numbers of av...

We screened 14,008 adult nonsurgical patients for Staphylococcus aureus nasal carriage at hospital admission and assessed them for invasive S. aureus disease and in-hospital mortality. Multilocus sequence typing was performed on endogenous invasive strains and nasal strains of matched asymptomatic carriers to investigate whether virulent clones could be identified in nasal carriers. Clonal comp...

Seasonal and perennial allergic rhinitis, acute rhinosinusitis and nasal polyposis are inflammatory conditions of the nose and/or sinuses that produce bothersome symptoms and markedly affect patients’ quality of life [1–3]. These diseases frequently coexist, suggesting that each may be a manifestation of an inflammatory process within the continuous airway [3–5]. Clinical treatment guidelines f...

BACKGROUND The present study investigated the effectiveness of a Pimpinella anisum-based herbal medicine for treating chronic rhinosinusitis (CRS) without polyps in comparison to fluticasone nasal spray, in a single-blinded randomized trial. METHODS Patients with CRS without nasal polyps were randomly assigned into 2 treatment groups: individuals in the first group (n = 26) received 2 drops o...

Previous work indicates that intranasal inhalation of oxytocin improves face recognition skills, raising the possibility that it may be used in security settings. However, it is unclear whether oxytocin directly acts upon the core face-processing system itself or indirectly improves face recognition via affective or social salience mechanisms. In a double-blind procedure, 60 participants receiv...

BACKGROUND Lack of trust in parental support is a transdiagnostic risk factor for the development of psychological problems throughout the lifespan. Research suggests that children's cognitive attachment representations and related information processing biases could be an important target for interventions aiming to build trust in the parent-child relationship. A paradigm that can alter these ...

Starting from the quantitative stability result of Bianchi and Egnell for the 2-Sobolev inequality, we deduce several different stability results for a Gagliardo-Nirenberg-Sobolev inequality in the plane. Then, exploiting the connection between this inequality and a fast diffusion equation, we get stability for the Log-HLS inequality. Finally, using all these estimates, we prove a quantitative ...