A change in the perception of the protein folding problem has taken place recently. The nature of the change is outlined and the reasons for it are presented. An essential element is the recognition that a bias toward the native state over much of the effective energy surface may govern the folding process. This has replaced the random search paradigm of Levinthal and suggests that there are ma...

The present study tested Japanese 4.5- and 10-month old infants' ability to discriminate three German vowel pairs, none of which are contrastive in Japanese, using a visual habituation-dishabituation paradigm. Japanese adults' discrimination of the same pairs was also tested. The results revealed that Japanese 4.5-month old infants discriminated the German /bu:k/-/by:k/ contrast, but they showe...

In 2 experiments, the authors examined the evolution of folkbiological reasoning in children (4 to 10 years of age) and adults from 4 distinct communities (rural Native American, rural majority culture, and suburban and urban North American communities). Using an adoption paradigm, they examined participants' intuitions regarding the inheritance of properties and the mechanisms underlying the t...

Fetal speech and language abilities were examined in 104 low-risk fetuses at 33-41 weeks gestational age using a familiarization/novelty paradigm. Fetuses were familiarized with a tape recording of either their mother or a female stranger reading the same passage and subsequently presented with a novel speaker or language: Studies (1) & (2) the alternate voice, (3) the father's voice, and (4) a...

A new paradigm in benchmark absorption-scattering radiative transfer is presented that enables both the globally averaged and spatially resolved testing of climate model radiation parameterizations in order to uncover persistent sources of biases in the aerosol instantaneous radiative effect (IRE). A proof of concept is demonstrated with the Geophysical Fluid Dynamics Laboratory AM4 and Communi...

In order for a Future Internet architecture to be globally deployed, it must ensure that existing applications will continue to operate efficiently on top of it. As part of the Publish Subscribe Internet Routing Paradigm (PSIRP) project, we have explored various options for making endpoint centric applications based on the Sockets Application Programming Interface (API) compatible with the info...

We present a software architecture for Java VMs and APIs that significantly increases the execution performance of Java applications on devices with considerable storage limitations. While present embedded Java devices usually implement standard API functions entirely in Java, we propose a shift of paradigm. By using a native programming language like C to implement the whole system library and...

Many attempts have been made to teach native Japanese listeners to perceptually differentiate English/r-l/(e.g. rock-lock). Though improvement is evident, in no case is final performance native English-like. We focused our training on the third formant onset frequency, shown to be the most reliable indicator of/r-l/category membership. We first presented listeners with instances of synthetic/r-...

Protein functional landscapes are characterized by a modest number of states compared with the folding landscapes, allowing brute force sampling of these states for smaller proteins using computer simulations. On the other hand, because the functional landscape topographies are complicated, the native state dynamics are often difficult to interpret. Nevertheless, a number of experimental and co...

To examine the influence of age and reading proficiency on the development of the spoken language network, we tested 6- and 9-years-old children listening to native and foreign sentences in a slow event-related fMRI paradigm. We observed a stable organization of the peri-sylvian areas during this time period with a left dominance in the superior temporal sulcus and inferior frontal region. A ye...