OBJECTIVE The authors’ laboratory has previously demonstrated beneficial effects of noninvasive low intensity focused ultrasound (liFUS), targeted at the dorsal root ganglion (DRG), for reducing allodynia in rodent neuropathic pain models. However, rats DRG is 5 mm below skin when approached laterally, while humans typically 5–8 cm deep. Here, using a modified liFUS probe, authors feasibility e...

It was shown that hyperglycemia in diabetic patients is the main factor of diabetic peripheral neuropathies. Various pathways related to oxidative stress, vascular defect and defective endothelium dependent relaxation have been implicated in the development of diabetic peripheral neuropathy. A substantial number of studies have shown that antioxidant treatment are promising therapeutics that ca...

Mathias Soeken, D. Michael Miller, and Rolf Drechsler Institute of Computer Science, University of Bremen, Germany Department of Computer Science, University of Victoria, BC, Canada The Pauli matrices are a set of three 2×2 complex Hermitian, unitary matrices. In this article, we investigate the relationships between certain roots of the Pauli matrices and how gates implementing those roots are...

MGluR2 is G protein-coupled receptor that is targeted for diseases like anxiety, depression, Parkinson's disease and schizophrenia. Herein, we report the three-dimensional quantitative structure-activity relationship (3D-QSAR) studies of a series of 1,3-dihydrobenzo[ b][1,4]diazepin-2-one derivatives as mGluR2 antagonists. Two series of models using two different activities of the antagonists a...

  Background : Determining the validity of current median sensory nerve conduction techniques for diagnosis of carpal tunnel syndrome (CTS).   Methods: Eighty five patients with clinical diagnosis of CTS were compared with the same number of healthy people. The validity of electrodiagnostic tests were compared in a case-control manner. These electrodiagnostictechniques included long-segment, sh...

Background Duchenne Muscular Dystrophy (DMD) is a deadly X-linked recessive disorder. This genetic disorder affects 1 among 3,500-5,000 males in the world. The majority of the patients are male, due to the type of inheritance. It affects most of the skeletal, the respiratory, and cardiac muscles, causing these vital organs to contract and eventually mortality.<br...

Hereditary motor and sensory neuropathies (HMSN) comprise a wide clinical spectrum of related disorders with defects in peripheral nerve myelination. More than 250 distinct mutations of the peripheral myelin protein 22 (PMP22), myelin protein zero (MPZ/P0), and connexin 32 (Cx32/GJB1) genes have been reported in patients diagnosed with different forms of hereditary motor and sensory neuropathie...

Charcot–Marie–Tooth disease (CMT) is one of the most common inherited neuropathy, with estimated prevalence of 17 to 40 in 100,000 affected (Patzkó, & Shy, 2011). CMT is characterized by atrophy of muscle tissue and loss of touch sensation of limb, predominantly in the feet and legs, foot drop, and hammer toes. The most frequent initial symptoms include foot drop, claw toe, and muscle wasting i...