The neural cell adhesion molecules (N-CAM) are a family of related glycoproteins with Mr of 180, 140 and 120 x 10(3) (180K etc.). In the embryo, they are often highly sialylated and migrate as a diffuse band of 170-250K. N-CAM are found in non-neural tissues and we have now studied the expression of N-CAM in the developing mouse kidney. During kidney development, a unique conversion of a mesenc...

Fibrosing mediastinitis (FM) is a rare benign disorder caused by proliferation of acellular collagen and fibrous tissue within the mediastinum. In the United States, most cases are thought to be caused by an abnormal immune response to Histoplasma capsulatum infection. Some cases of FM are related to tuberculosis. In most patients the cause of FM is unknown. The affected patients are typically ...

INTRODUCTION Nephrogenic systemic fibrosis is a condition that has recently been recognized in patients with chronic renal disease and is associated with use of gadolinium-based contrast agents of ubiquitous use in magnetic resonance imaging scans. The condition is believed to arise through inadequate renal clearance of the gadolinium-based contrast agents, resulting in bodily deposition of the...

BACKGROUND Nephrogenic systemic fibrosis may be caused by gadolinium (Gd)-containing magnetic resonance imaging contrast agents. Most reported cases were associated with one particular agent, gadodiamide. Yet, unidentified cofactors might explain why only a minority of renal failure patients exposed to gadodiamide develop nephrogenic systemic fibrosis. METHODS We conducted a case-control stud...

A hormonal etiology has been defended due to the observation of the disorder in menopausal women [2,3]. Recently, the coexistence of frontalfibrosing alopecia with autoimmune diseases, such as lupus erythematosus and vitiligo, has contributed to an immunological basis in its pathogenesis [4,5]. There are no data of frontalfibrosing alopecia associated with hepatitis C treatment with interferon ...

SEE PAGE 1019 C ardiac magnetic resonance (CMR) late gadolinium enhancement (LGE) (1) is the current clinical gold standard modality for evaluation of focal fibrosis and scar in patients with an ischemic or a nonischemic cardiomyopathy. LGE requires administration of an exogenous gadoliniumbased contrast agent, which accumulates in the scar region. LGE imaging is commonly performed using an inv...

Objective: To report an unusual case of extrarenal nephroblastomatosis involving bilateral inguinal regions. Background: Nephroblastomatosis and nephrogenic rests are usually found in neonatal kidneys sub-clinically or associated with Wilms tumor. Extrarenal occurrence of this immature renal tissue is reported in literature as an incidental finding seen in inguinal canal, retroperitonium, along...

Background The presence and transmurality of posterolateral scar within the left ventricle by late gadolinium enhancement (LGE) imaging has been shown to portend poor response to cardiac resynchronization therapy due to placement of the LV lead in this region. Unfortunately, the use of gadolinium is contraindicated in patients with significant renal dysfunction due to the risk of nephrogenic sy...

Magnetic resonance imaging (MRI) and computed tomography (CT) have become essential to diagnostic evaluation of many, or most, important medically and surgically treated diseases. It is important to consider comprehensively the implications in making decisions when choosing one or the other cross-sectional imaging modality. Factors to consider include the relative risks of the contrast agent. O...

Acute kidney injury (AKI) is a common complication of hospitalization that is characterized by a sudden loss of renal excretory function and associated with the subsequent development of chronic kidney disease, poor prognosis, and increased mortality. Although the pathophysiology of renal functional impairment in the setting of AKI remains poorly understood, previous studies have identified cha...