Nephrotoxicity is defined as renal dysfunction that arises as result of exposure to external agents such as drugs and environmental chemicals. The present work was undertaken to carry out the phytochemical study and nephroprotective activity of methanolic extract of Casuarina equisetifolia leaves in gentamicin-induced nephrotoxicity in Wistar rats. Flavonoids and phenolic acids were identified ...

Hypertension occurs about twice as frequently in diabetics as in the general population, with a prevalence of approximately 25% in young patients with insulin-dependent diabetes mellitus (IDDM) and 50% in patients with newly diagnosed non-insulin-dependent diabetes mellitus (NIDDM). Studies strongly suggest that hypertension is involved in the progression and perhaps the onset of diabetic nephr...

Environmental pollution from pesticides is an important issue that attracts wide spread public concern. Among these organophosphate pesticides are routinely used in agriculture. Chloropyrifos toxicity has been largely associated with irreversible inhibition of acetyl-cholinesterase resulting in accumulation of acetylcholine in the cholinergic receptors. Organochlorine insecticides, caused degen...

Ginsenoside Rk1 (G-Rk1) is a unique component created by processing the ginseng plant (mainly Sung Ginseng (SG)) at high temperatures. The aim of our study was to systematically review the pharmacological effects of G-Rk1. We utilized and manually searched eight databases to select in vivo and in vitro original studies that provided information about biological, pharmaceutical effects of G-Rk1 ...

Aim: The aim of this study was to evaluate the effects Harungana madagascariensis stem bark ethyl acetate extract with antioxidants on liver and kidney in rats.
 Study Design: Experimental.
 Place Duration Study: Department Veterinary Pharmacology Toxicology, University Ibadan (from January-February, 2020).
 Methodology: This done using Albino rats (Wistar) grouped into 12 5 anim...

Background: Kidneys exposure to toxins can cause injuries, leading to their functional impairments. Traditionally, plants have been used for the treatment of renal disorders and numerous medicinal plants have been tested for their nephroprotective effects, in such cases as gentamicin (GM) and cisplatin (Cisp)-induced nephrotoxicity. This study assessed the ability of Acalypha wilkesiana’s extra...