Atopic dermatitis (AD) is an inflammatory skin disease in which epidermal barrier impairment, often owing to FLG null mutations, precedes immune hyperresponsiveness. Ichthyosis vulgaris characterized by mutations and noninflamed dry skin. Netherton syndrome (NS), caused SPINK5 generalized erythroderma with scaling atopic manifestations. The goal of this work was evaluate associations between sp...

Ichthyoses form a heterogeneous group of well-defined inherited skin diseases. However, the comorbidity these cornification disorders needs to be further investigated, as psoriasiform lesions and/or atopic manifestations may observed in many affected individuals. We recruited 64 patients with ichthyoses, 29 psoriasis and 37 dermatitis (AD) patients, assessed disease severity by Ichthyosis Area ...

Tissue kallikreins (KLKs), in particular KLK5, 7 and 14 are the major serine proteases in the skin responsible for skin shedding and activation of inflammatory cell signaling. In the normal skin, their activities are controlled by an endogenous protein protease inhibitor encoded by the SPINK5 gene. Loss-of-function mutations in SPINK5 leads to enhanced skin kallikrein activities and cause the s...