An endocrine carcinoma of the left parotid salivary gland in a 58-year-old woman is reported. The tumour displayed a large argyrophilic cell-component and at ultrastructural level endocrine-like granules (ELG) were evident. As endocrine-paracrine cells are not normally present in the parotid, it is suggested that the endocrine elements may have been derived from an anomalous differentiation of ...

Endocrine tumours of the gastrointestinal tract and pancreas may present at different disease stages with either hormonal or hormone-related symptoms/syndromes, or without hormonal symptoms. They may occur either sporadically or as part of hereditary syndromes. In the therapeutic approach to a patient with these tumours, excessive hormonal secretion and/or its effects should always be controlle...

Nutrient homeostasis is known to be regulated by pancreatic islet tissue. The function of islet -cells is controlled by a glucose sensor that operates at physiological glucose concentrations and acts in synergy with signals that integrate messages originating from hypothalamic neurons and endocrine cells in gut and pancreas. Evidence exists that the extrapancreatic cells producing and secreting...

Objective(s): Gallium‐68 (Ga‐68) is an ideal research and hospital‐based PET radioisotope. Currently, the main form of Ga‐68 radiopharmaceutical that is being synthesised in‐house is Ga‐68 conjugated with DOTA based derivatives. The development of automated synthesis systems has increased the reliability, reproducibility and safety of radiopharmaceutical productions. Here we report on our three...

Supratentorial diffuse intrinsic low-grade gliomas represent a distinct but heterogenous group of tumours, with the propensity to grow and to differentiate into malignant tumours. They have been historically viewed in the 'benign' spectrum of intrinsic brain tumours, so a watch-and-wait policy was often adopted. With recent advances in our understanding of the natural history of these tumours, ...

Somatostatin is a regulatory hormone or tissue factor which plays an inhibitory role in the normal regulation of several organ systems, including the central nervous system, hypothalamus and pituitary gland, the gastrointestinal tract and the exocrine and endocrine pancreas. Sandostatin is an analogue of somatostatin which has characteristics which makes it a better compound for clinical use th...

glucose positron emission tomography uptake in a giant adrenal myelolipoma. Mol Imaging Biol 2002;4:355–8. 5 Hennings J, Hellman P, Ahlstrom H et al. Computed tomography, magnetic resonance imaging and 11C-metomidate positron emission tomography for evaluation of adrenal incidentalomas. Eur J Radiol 2007;69:314–23. 6 Khan TS, Sundin A, Juhlin C et al. 11-C metomidate PET imaging of adrenocortic...

THE most well-known types of hormone-dependent tumours are those of breast, endometrium and prostate, but several other types probably exist (Crowley, 1969; Crowley & Duwe, 1969). Because of their special nature they are open to endocrine manipulation in ways not possible in other tumours. Tumours of the ovary are not easily characterized in this respect as there are so many types and several a...