Neuroendocrine cells are specialized to produce, maintain and release large stores of secretory peptides. We show that the Drosophila dimmed/Mist1 bHLH gene confers such a pro-secretory phenotype on neuroendocrine cells. dimmed is expressed selectively in central and peripheral neuroendocrine cells. In dimmed mutants, these cells survive, and adopt normal cell fates and morphology. However, the...

Some breast neoplasms are classified as primary neuroendocrine carcinomas because they are positive for neuroendocrine markers. Although neuroendocrine carcinomas can originate from various organs of the body, primary neuroendocrine carcinomas of the breast are extremely rare. The diagnosis of primary neuroendocrine carcinoma of the breast can only be made if nonmammary sites are confidently ex...

Neuroendocrine tumor of the lung is classified into four subtypes according to the recent World Health Organization Classification: typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma (LCNEC) [1]. LCNEC is a relatively rare histopathological subtype of lung carcinoma, which accounts for approximately 3% of all lung carcinomas [1]. It has been wel...

Concurrence of adenocarcinoma and large-cell neuroendocrine carcinoma of the stomach is a rare condition. Here, we report a case of gastric collision tumour with large-cell neuroendocrine carcinoma and adenocarcinoma. A 71-year-old Peruvian man presented with nausea, epigastric pain, and weight loss for seven months. An Endoscopic evaluation revealed a huge ulcerative and infiltrative mass in t...

We report a case of coexisting poorly differentiated endocrine carcinoma and conventional adenocarcinoma in the ampulla of Vater. A 70-year-old female had a recent history of symptoms and signs related to obstructive jaundice. An initial endoscopic biopsy of the ampulla of Vater showed a poorly differentiated endocrine carcinoma in the lamina propria of duodenal mucosa. The tumor could also be ...

Synaptophysin is a M, 38,000 integral membrane glycoprotein ex pressed by a variety of normal and neoplastic neuroendocrine cells. \Ve studied Synaptophysin as an immunocytochemical marker for neuroen docrine differentiation in lung cancer and compared it to the immunocy tochemical expression of chromogranin A, a marker for dense core (endocrine) granules, and the biochemical activity of i.-dop...