This paper aims to evaluate the anti-emetic efficacy of cannabinoids in cancer patients receiving chemotherapy using a systematic review of literature searched within electronic databases such as PUBMED, EMBASE, PSYCINFO, LILACS, and 'The Cochrane Collaboration Controlled Trials Register'. Studies chosen were randomized clinical trials comprising all publications of each database until December...

How "malignant" is the neuroleptic malignant syndrome? In early mild cases it may not be malignant at all Although cases of acute fatal psychoses associated with fever and neuromuscular disturbance have been reported sporadically since the nineteenth century' and the propensity for neuroleptic drugs to disrupt neuromuscular function has been described as their use has grown, the entity of the "...

T-type calcium channels play critical roles in cellular excitability and have been implicated in the pathogenesis of a variety of neurological disorders including epilepsy. Although there have been reports that certain neuroleptics that primarily target D2 dopamine receptors and are used to treat psychoses may also interact with T-type Ca channels, there has been no systematic examination of th...

In the present experiments, the dose-response effects or the dopamine (DA) receptor antagonists haloperidol, pimozide, clozapine, sulpiride. and metoclopramide, were assessed on patterns of copulatory behavior in intact, sexually active male rats with a high level of sexual experience and performance. The typical neuroleptics haloperidol (0.01-0.5 mg/kg) and pimozide (0.1-5.0Omg/kg) dose-depend...

OBJECTIVES To summarize the quality of evidence for the efficacy of different biological treatments in mania, mixed state, and rapid cycling and to propose guidelines for treatment of these conditions. METHOD Articles published on treatment of acute mania, mixed states, and rapid cycling were reviewed and rated for quality of evidence using Periodic Health Examination guidelines. RESULTS Li...

The sigma site is a recently described binding site to which dextrorotary isomers of certain psychotomimetic benzomorphans bind specifically. Classical and nonclassical neuroleptics also have high affinity for the sigma site, including neuroleptics known to bind to the D2 dopamine receptor. The affinity of some D2-binding neuroleptics for the sigma site has raised the possibility that certain i...

BACKGROUND A cost-sharing drug insurance plan has been implemented among people receiving social assistance who had previously free access to medications. OBJECTIVE To assess the impact of this drug plan on the use of three classes of medications: inhaled corticosteroids, neuroleptics and anticonvulsants. METHODS From the computerized drug databases of the Régie de l'assurance maladie du Qu...

The pharmacological profiles of the atypical antipsychotics, clozapine, olanzapine, quetiapine and risperidone, all show a combined serotonin (5-HT2) and dopamine type-2 (D2) receptor antagonism. Amisulpride, a highly selective dopamine D2/D3 receptor antagonist that binds preferentially to receptors in the mesolimbic system, is also an 'atypical' antipsychotic despite having a different recept...

Neuroleptics can induce not only physical adverse effects but also mental effects that produce deficit status in thought, affect, cognition, and behavior. This condition is known as neuroleptic-induced deficit syndrome (NIDS), which includes apathy, lack of initiative, anhedonia, indifference, blunted affect, and reduced insight into disease. Although this old concept now appears almost forgott...

Today, asthenia is one of the most common syndromes in practice a doctor any specialty. Her treatment uses comprehensive approach that includes physical training, psychotherapy, diet and pharmacotherapy. Pharmacotherapeutic appointment antidepressants, nootropics, tranquilizers, psychostimulants, neuroleptics. Given multimodality multilevel nature lesion nervous system C?VID-19, recovery period...