We report a new syndrome that we call "recurrent optic neuromyelitis with endocrinopathies" in eight Antillean women from Martinique and Guadeloupe Ocular involvement was either monocular or binocular, whereas myelopathy was acute or subacute. In seven patients, myelopathic symptoms recurred, and in six patients, visual problems recurred. Spinal cord involvement was a consistent band-like pseud...

Sir, We appreciate the thoughtful commentary from Drs Lujan and Horton (2013) based on their patient with Kjer’s dominant optic atrophy with retinal inner nuclear layer microcysts. Their case highlights an emerging understanding that inner nuclear microcysts are not specific to multiple sclerosis. We—and others— have now identified them in neuromyelitis optica (Gelfand et al., 2013; Sotirchos e...

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory of the central nervous system (CNS) known for its predilection spinal cord, optic nerves, and brainstem. However, headache more specifically idiopathic intracranial hypertension (IIH) unusual presentation disease. Here, we present a 40-year-old female, who initially presented in our department neurology with refractory headache, ...

I n their excellent review of neuromyelitis optica (NMO), Morrow and Wingerchuk (1) discuss the criteria that distinguish this condition from multiple sclerosis. Here, we describe diffusion-weighted magnetic resonance imaging (DWI) of the optic nerve in a patient with NMO-associated optic neuropathy. A 21-year-old man developed vision loss in the right eye that was diagnosed as optic neuritis. ...

A 22-year-old woman presented with photopsia, sensory loss, and paresthesia over both lower extremities, visual scotomas, and painless binocular vision loss over 5 months. MRI showed T2 hyperintensities near the optic chiasm (figure 1, B and C), floor of the fourth ventricle and the colliculi (figure 2, A–F), and central gray matter of the spinal cord (figure 1A). CSF analysis was notable for e...

Objective This study aims to describe the clinical manifestations and outcomes in a cohort of older Chinese patients. Method A retrospective study of patients aged ≥ 45 years who had a first episode of optic neuritis (ON) between May 2008 and November 2012. Clinical features at onset and last follow-up were analyzed within subgroups (age 45-65 years and age ≥ 65 years). Results 76 patients ...