نتایج جستجو برای: neuronal differentiation
تعداد نتایج: 334318 فیلتر نتایج به سال:
Mesenchymal stem cells (MSCs) are self-renewing found in almost all postnatal organs and tissues the perivascular region. These present multiple characteristics that make them candidates to be applied cell therapy for neurodegenerative diseases, such as their secretory action, migration lesion area, immunomodulatory potential. have a high capacity mesodermal differentiation; however, numerous s...
The NR1 gene undergoes induction in neurogenesis mainly via promoter de-repression, and up-regulation during neuronal differentiation by undefined mechanism(s). Here, we show that in the distal region the NR1 promoter has an active NFB site sharing the consensus with the immunoglobulin (Ig)/human immunodeficiency virus NFB site. Mutation of this site significantly reduced NR1 promoter up-regula...
Cerebral ischemia and neurodegenerative diseases lead to impairment or death of neurons in the central nervous system. Stem cell based therapies are promising strategies currently under investigation. Carbon monoxide (CO) is an endogenous product of heme degradation by heme oxygenase (HO) activity. Administration of CO at low concentrations produces several beneficial effects in distinct tissue...
Although valproic acid (VPA), has been shown to induce neuronal differentiation of neural stem cells (NSCs), the underlying mechanisms remain poorly understood. Here we investigated if and how mammalian target of rapamycin (mTOR) signaling is involved in the neuronal differentiation of VPA-induced NSCs. Our data demonstrated that mTOR activation not only promoted but also was necessary for the ...
Brain regionalisation, neuronal subtype diversification and circuit connectivity are crucial events in the establishment of higher cognitive functions. Here we report the requirement for the transcriptional repressor Fezf2 for proper differentiation of neural progenitor cells during the development of the Xenopus forebrain. Depletion of Fezf2 induces apoptosis in postmitotic neural progenitors,...
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