Osteoblastic bone metastases are common in prostate and breast cancer patients, but mechanisms by which tumor cells stimulate new bone formation are unclear. We identified three breast cancer cell lines that cause osteoblastic metastases in a mouse model and secrete endothelin-1. Tumor-produced endothelin-1 stimulates new bone formation in vitro and osteoblastic metastases in vivo via the endot...

INTRODUCTION Demineralised bone matrix (DBM) is an allograft material widely used as a bone filler and bone graft substitute. DBM contains bone morphogenetic proteins (BMPs), which induce and regulate bone formation during embryogenesis and in postnatal life. AIMS AND OBJECTIVES To investigate the osteoinductivity of DBM augmented with xenogeneic BMP-complex at different doses. MATERIALS AN...

Background: To overcome the limited source of autogenous bone in bone grafting, many efforts have been made to find bone substitutes. The use of hybrid composites of silk and hydroxyapatite to simulate natural bone tissue can overcome the softness and brittleness of the individual components. Methods: Critical-sized, 7 x 4 x 1.5 mm alveolar defects were created surgically in 36 Sprague-Dawley r...

Tissue development and regeneration is regulated by an interplay among various tissue inductive growth factors, formation of an appropriate vascular bed to support the metabolic needs of the forming tissue mass, and a cell population capable of responding to the chemical cues and creating the new tissue. There has been considerable interest in understanding this signaling interplay in bone, due...

objective: osseous defects around dental implants are often seen when implants are placed in areas with inadequate alveolar bone, or around failing implants. bone regeneration in these areas using bone grafts or its substitutes may improve dental implants prognosis. the aim of this study was to prepare and characterize the bioactive glass nanopowder and development of its coating for treatment ...

OBJECTIVES The purpose of the present study was to evaluate bone healing in rabbit critical-sized calvarial defects using two different synthetic scaffold materials, solid biodegradable bioactive glass and tricalcium phosphate granules alongside solid and particulated autogenous bone grafts. MATERIAL AND METHODS Bilateral full thickness critical-sized calvarial defects were created in 15 New ...

We investigated the interaction between angiogenic and osteogenic factors in bone formation and bone healing with ex vivo gene therapy using muscle-derived stem cells genetically engineered to express human bone morphogenetic protein-4 (BMP4), VEGF, or VEGF-specific antagonist (soluble Flt1). Our results show that although VEGF alone did not improve bone regeneration, it acted synergistically w...

A 70-year-old man with florid symptoms of hypertrophic osteoarthropathy for over a year presented without radiographic evidence of new bone formation. His symptoms improved after exploratory thoracotomy, but recurred with lesser severity a year later with tumour recurrence on the chest wall. Absence of new bone formation was again demonstrated radiologically as well as by isotope scan.

BACKGROUND Radiographic examination of extremities in surgical lengthening and/or correction of deformities is of crucial importance for the assessment of new bone formation. The purpose of this study is to confirm the diagnostic value of radiography in precise detection of bone parameters in various lengthening or correction stages in patients treated by limb-lengthening and deformity correcti...