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تعداد نتایج: 2031383 فیلتر نتایج به سال:
We present preliminary results from a deep (600 ks) Chandra observation of the hot interstellar medium of the nearby early-type galaxy Centaurus A. We find a surface brightness discontinuity in the gas ∼3.5 kpc from the nucleus spanning a 120 arc. The temperature of the gas is keV ( keV) interior (exterior) to the 0.60 0.05 0.68 0.10 discontinuity. The elemental abundance is poorly constrained ...
in the recent years, targeted therapy of the neoplastic diseases is a current strategy used by oncologists. hence, design and discovery of novel targeted anticancer therapeutics is an interesting topic in the current research of medicinal chemistry. a new series of 1,3,4-thiadiazole derivatives were prepared and their anticancer activity was assessed against pc3, sknmc and ht29 cell lines by ap...
background: heme oxygenase-1 (ho-1) is a cytoprotective and antiapoptotic enzyme, which has been involved in maintaining cellular homeostasis, and plays an important protective role by modulating oxidative injury. up-regulation of (ho-1) has contributed to tumorogenicity of some cancers. in this study we investigated the expression pattern of the ho-1, in five different human-derived cancer cel...
This paper deals with violent discontinuities in shallow water flows with large Froude number F . On a horizontal base, the paradigm problem is that of the impact of two fluid layers in situations where the flow can be modelled as two smooth regions joined by a singularity in the flow field. Within the framework of shallow water theory we show that, over a certain timescale, this discontinuity ...
We study Nf D6-brane probes in the supergravity background dual to Nc D4branes compactified on a circle with supersymmetry-breaking boundary conditions. In the limit in which the resulting Kaluza–Klein modes decouple, the gauge theory reduces to nonsupersymmetric, four-dimensional QCD with Nc colours and Nf ≪ Nc flavours. As expected, this decoupling is not fully realised within the supergravit...
We present high resolution UVES+VLT spectroscopic observations of 61 stars in the extended blue horizontal branches of the Galactic globular clusters NGC 1904 (M79), NGC 2808, NGC 6093 (M80), and NGC 7078 M15). Our data reveal for the first time the presence in NGC 1904 of a sizable population of fast (vsini ≥ 20 km/s) horizontal branch (HB) rotators, confined to the cool end of the EHB, simila...
Quinoxalines display diverse and interesting pharmacological activities as antibacterial, antiviral, antiparasitic and anticancer agents. Particularly, their 1,4-di-N-oxides derivatives have proved to be cytotoxic agents that are active under hypoxic conditions as that of solid tumours. A new series of quinoxaline 1,4-di-N-oxides substitutes at 7-position with esters group were synthetized and ...
Quinoxalines display diverse and interesting pharmacological activities as antibacterial, antiviral, antiparasitic and anticancer agents. Particularly, their 1,4-di-N-oxides derivatives have proved to be cytotoxic agents that are active under hypoxic conditions as that of solid tumours. A new series of quinoxaline 1,4-di-N-oxides substitutes at 7-position with esters group were synthetized and ...
Two set of 2-aryl-5,6-dihydropyrrolo[2,1-a] isoquinolines were designed and synthesized to evaluate their biological activities as topoisomerase inhibitors. Cytotoxic activity of the synthesized compounds 4a-e and 7a-d was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HepG2 (liver hepatocellular cells), A549 (adenocarcinomic human alveolar basal epithel...
Drylands cover about 6.2 million hectares of arable lands across Iran, but annual feed legumes are not present in rainfed crop rotations. Introduction of new forage cultivars with high productivity and nutritive values is a key solution in drylands development. Vd-2446 a vetch (Vicia dasycarpa) line with origin of Italy has been selected from vetch nurseries provided by ICARDA during 1995 a...
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