to correct a Unicode character in the seventh sentence of the Abstract: " NFκB " should be " NFκB. " The publisher apologizes for the error. Please download this article again to view the correct version. open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original...

Background: Hepatitis C is a global health problem. The exact mechanisms by which hepatitis C virus (HCV) can evade the host immune system have become controversial. Whether HCV polyproteins modulate IFN signalling pathways or HCV proteins are responsible for such a property is the subject of interest. Therefore, an efficient baculovirus delivery system was developed to introduce the whole geno...

Ovarian aging is a natural process in females, and it occurs due to an elevated ROS-induced inflammation caused by oxidative stress. SIRT-1 metabolic sensor that tightly regulates inflammatory responses. However, this regulative function antagonized NFκB. Therefore, the objective of study was explore pathways involved identify flavonoid compounds from Marsilea crenata might be useful as SIRT1 a...

Although the noncanonical NFκB pathway was originally identified as a cellular contributing to lymphoid organogenesis, in past 20 years, its involvement innate immunity has become more appreciated. In particular, been found be activated and even exploited by some RNA viruses during infection. Intriguingly, activation of this shown have role disrupting transcription type 1 interferon (IFN), sugg...

The induction of senescence in tumor cells impairs transformation and promotes an anticancer immune response resulting from the production by senescent cells of cytokines and chemokines, an aspect known as "senescence-associated secretory phenotype" (SASP). Here we discuss recent findings regarding the role of NFκB in the modulation of the SASP and the consequent anticancer immune response.

In the first paragraph in the " Gene Expression Profiling " section, the third sentence should say, " In particular, cases with higher levels of NFκB-related molecules or other evidence of NFκB activation showed better survival, with a median OS of 25 months (range 0–124 months) versus a median OS of 12 months (range 0–19 months) (P=0.032) [36, 38]. " The online version of the original article ...

Abstract Psoriasis is a common chronic inflammatory skin disease. One of the hallmarks psoriasis abundance neutrophil infiltration in lesions. However, detailed molecular mechanisms chemotaxis and activation remains unclear. Here we demonstrated an upregulation epidermal fatty acid binding protein (E-FABP, also known as FABP5) tissue from both human imiquimod (IMQ)-induced psoriatic mouse model...

Immune responses must be well restrained in a steady state to avoid excessive inflammation. However, such restraints are quickly removed to exert antimicrobial responses. Here we report a role of autophagy in an early host antifungal response by enhancing NFκB activity through A20 sequestration. Enhancement of NFκB activation is achieved by autophagic depletion of A20, an NFκB inhibitor, in F4/...

BACKGROUND Pentoxifylline has anti-inflammatory properties and could suppress some inflammatory processes including tumor necrosis factor-alpha (TNF-α) production. We assessed the effects of a two-month administration of pentoxifylline on nuclear factor-kappa B (NFκB) pathways in patients with coronary artery disease (CAD) in which inflammatory pathways, especially NFκB transcription factors, h...