Our research group have been working on transistion metal complexes and their activity in the biology field, especially antimicrobial and anticancer properties. Novel pseudohalide ligands with orotic acid and its metal salt Ni(II) have been synthesized and evaluated for their antimicrobial activities by disc diffusion method. The complexes have been characterized by IR, SEM, Raman, P-Xrd and UV...

2-Hydroxy-3-methoxy benzaldehyde thiosemicarbazone has been synthesized, characterized and its analytical application investigated. It reacts with nickel(II) in aqueous solution at pH 4.0-8.0 and at room temperature to form a yellow coloured ML (1:1) complex with absorption maximum at 410 nm and molar absorptivity 2.05×10 l mol cm. Beer’s law is obeyed in the range of 0.058-2.347 μg ml of Ni(II...

In the title mononuclear nickel(II) complex, [Ni(C(13)H(15)ClNO)(2)], the Ni(II) atom is four-coordinated in a tetra-hedral geometry by the N and O atoms of the two Schiff base ligands.

[Ni3(C2H3 0 2 )2(CH3 0 H)2L2] [L = l,3-bis(5-chlorosalicylideneamino)propan-2-ol dianion, (C2H3 0 2 )_ = acetate, (CH3OH) = methanol] was synthesized and its crystal structure was determined. It crystallizes in the monoclinic spaceeroup P2i /n with a = 12.694(2), b = 13.281 (4), c = 15.420(3) Ä, ß = 111.25(2)°, V = 2422.9(9) A ? ,Z = 2 . The molecule is a “linear” trinuclear complex with nearly...

The [NiFe] centers at the active sites of the Escherichia coli hydrogenase enzymes are assembled by a team of accessory proteins that includes the products of the hyp genes. To determine whether any other proteins are involved in this process, the sequential peptide affinity system was used. The analysis of the proteins in a complex with HypB revealed the peptidyl-prolyl cis/trans-isomerase Sly...

The nitrogen-scavenging enzyme urease has been coopted in a variety of pathogenic organisms as a virulence factor, most notoriously to neutralize stomach acid and establish infection by the gastric pathogen Helicobacter pylori. The opportunistic fungal pathogen Cryptococcus neoformans also utilizes urease as a virulence factor, only in this case to invade the central nervous system (CNS) via th...

The siderophore-based extraction of iron from the soil by bacteria is proposed as a model for a new separation methodology labeled the soil poultice, a molecular device that would selectively retrieve the complex of a targeted metal ion. In this first feasibility study we describe the synthesis and characterization of molecularly imprinted polymers based on noncovalent interactions, and their a...

Air and moisture stable homoleptic bis(diimidazolylidine)nickel(II) complexes, ([(diNHC)(2)Ni](2+)) 3a,b and their corresponding silver(I) 4a,b and palladium(II) 5a,b complexes were synthesized and characterized by NMR and single crystal X-ray analysis. The catalytic potential of complex 3a was assessed in Mizoroki-Heck and Suzuki-Miyaura coupling reactions. In the Suzuki-Miyaura coupling react...

Many nickel-based catalysts have been reported for cross-coupling reactions of nonactivated alkyl halides. The mechanistic understanding of these reactions is still primitive. Here we report a mechanistic study of alkyl-alkyl Kumada coupling catalyzed by a preformed nickel(II) pincer complex ([(N2N)Ni-Cl]). The coupling proceeds through a radical process, involving two nickel centers for the ox...