Tungsten-alloy has carcinogenic potential as demonstrated by cancer development in rats with intramuscular implanted tungsten-alloy pellets. This suggests a potential involvement of epigenetic events previously implicated as environmental triggers of cancer. Here, we tested metal induced cytotoxicity and epigenetic modifications including H3 acetylation, H3-Ser10 phosphorylation and H3-K4 trime...

Background: Metal pollution is a problem in many parts of the world. These metals can be harmful when they exceed the recommended limits. By analyzing metal concentrations in living organisms, it is possible to deduce the bioavailability and the level of environmental contamination for specific metals in an ecosystem. The aim of this study was to determine the heavy metals copper, cadmium, lead...

At present, nanoparticles are beginning to influence our lives in many ways and understanding the environmental health and safety aspect of nanomaterials has become a crucial issue. The aim of the work was to assess and compare the acute toxicity of 31 different nanomaterials to fish mature individuals Danio rerio with that to fish early life stages on using evaluation of the 48- and 96- hour L...

by producing reactive oxygen and nitrogen species, metal-induced toxicity and carcinogenicity alter dna bases, increase  lipid peroxidation, and change calcium and sulfhydryl homeostasis. the purpose of the study was to investigate putative effects of lemon balm and cinnamomum zeylanicum on the blood markers of welding workers. we measured nickel and chromium levels, biochemical parameters, blo...

While insoluble nickel subsulfide (Ni3 S2 ) was carcinogenic in the lung in a 2-year rat bioassay, soluble nickel sulfate hexahydrate (NiSO4* 6H2 O) was not. To investigate whether differences in the cellular responses to these two nickel compounds could underlie their differential activities, we conducted parallel studies to determine the gene expression changes in micro-dissected lung distal ...

The relationship between oxidative stress and carcinogenic metals including nickel and cadmium is a matter of interest. To assess the oxidative stress status of workers exposed to nickel and cadmium simultaneously, we determined urinary excretion of 8-hydroxyguanine (8-OH-Gua), a urinary oxidative stress marker. Our subjects were 66 (64 males and 2 females) nickel-cadmium battery workers. Spot ...

To better understand the molecular mechanism(s) involved in the essentiality, toxicity, and/or carcinogenicity of nickel compounds, a niKN A differential display technique was used to identify gene(s) that were specifically induced by these carcinogens. Differential expression of sev eral genes was observed in human lung A549 cells exposed to nickel subsulfide. One gene, Cap43, which expressed ...

Conventional electroless nickel–boron deposits are produced using solutions that contain lead or thallium, which must be eliminated due to their toxicity. In this research, were in a stabilizer-free bath does not include any toxic heavy metal. During processing, the plating rate increased from 10 14.5 µm/h by decreasing concentration of reducing agent, leading stability. The thickness, composit...